Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

Artemisinin derivatives are the most recent single drugs approved and introduced for public
antimalarial treatment. Although their recommended use is for treatment of Plasmodium …

The application of artemisinin (ART) in the treatment of malaria has been restricted to a
certain degree due to its inherent limitations, such as short half-life, poor solubility, limited …

Propargylamines have been synthesized by a gold (III) salen complex-catalyzed three-
component coupling reaction of aldehydes, amines, and alkynes in water in excellent yields …

A major impediment to effective anti-leishmanial chemotherapy is the emergence of drug
resistance, especially to sodium antimony gluconate, the first-line treatment for …

Pharmaceutical monotherapies against human malaria have proven effective, although
ephemeral, owing to the inevitable evolution of resistant parasites. Resistance to two or …

Leishmaniasis affects over 150 million people all over the world, especially in subtropical
regions. Currently used antileishmanial synthesized drugs are associated with some …

Drugs are primary weapons for reducing malaria in human populations. However
emergence of resistant parasites has repeatedly curtailed the lifespan of each drug that is …

Malaria is a vector-borne infectious disease caused by the protozoan Plasmodium parasites.
Each year, it causes disease in approximately 515 million people and kills between one and …

Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and
Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin …