Because they mainly do not involve chemical changes, membrane transporters have been a
Cinderella subject in the biotechnology of small molecule production, but this is a serious …

Cell size is highly variable; cells from various tissues differ in volume over orders of
magnitudes, from tiny lymphocytes to giant neurons, and cells of a given type change size …

Nucleosomes are disrupted during transcription and other active processes, but the
structural intermediates during nucleosome disruption in vivo are unknown. To identify …

We present an experimental and computational pipeline for the generation of kinetic models
of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae …

We investigated the systems response of metabolism and growth after an increase in
irradiance in the nonsaturating range in the algal model Chlamydomonas reinhardtii. In a …

Over the years, my colleagues and I have come to realise that the likelihood of
pharmaceutical drugs being able to diffuse through whatever unhindered phospholipid …

Recent research suggests that genetic interactions involving more than two loci may
influence a number of complex traits. How these 'higher-order'interactions arise at the …

Classic genetics studies found that genomic imbalance caused by changing the dosage of
part of the genome (aneuploidy) has more detrimental effects than altering the dosage of the …

Cells balance glycolysis with respiration to support their metabolic needs in different
environmental or physiological contexts. With abundant glucose, many cells prefer to grow …

The increasing application of next generation sequencing approaches to the analysis of
human exome and whole genome data has enabled the identification of novel variants and …