Background The use of novel algorithmic techniques is pivotal to many important problems
in life science. For example the sequencing of the human genome [1] would not have been …

This review summarizes important work in open-source bioinformatics software that has
occurred over the past couple of years. The survey is intended to illustrate how programs …

Background High-throughput or next-generation sequencing (NGS) technologies have
become an established and affordable experimental framework in biological and medical …

Background A large number of bioinformatics applications in the fields of bio-sequence
analysis, molecular evolution and population genetics typically share input/ouput methods …

Breakthroughs in gene sequencing technologies have led to an exponential increase in the
amount of genomic data. Efficient tools to rapidly process such large quantities of data are …

Concepts are an essential language feature for generic programming in the large. Concepts
allow for succinct expression of constraints on type parameters of generic algorithms, enable …

In the open-field behavior of rodents, Software for Exploring Exploration (SEE) can be used
for an explicit design of behavioral endpoints with high genotype discrimination and …

Generic programming is an effective methodology for developing reusable software
libraries. Many programming languages provide generics and have features for describing …

Support for object-oriented programming has become an integral part of mainstream
languages, and more recently generic programming has gained widespread acceptance as …

Organoids present immense promise for studying organ systems and their functionality.
Recently, they have become the subject of exploration outside of purely biomedical uses in …