Background Numerous experimental studies, conducted primarily over the past 10 years,
show that there are sex differences in opioid analgesia. This review summarizes the …

In recent years it has become apparent that sex is a major factor involved in modulating the
pharmacological effects of exogenous opioids. The kappa opioid receptor (KOPR) system is …

This paper is the twenty-third installment of the annual review of research concerning the
opiate system. It summarizes papers published during 2000 that studied the behavioral …

Estradiol affects the structure and function of the hippocampus. We have found that repeated
estradiol affects neurogenesis and cell death in the hippocampus of adult female, but not …

A number of investigators have shown that sex plays an important role in the analgesic
effects of opioids. Typically, the antinociceptive responsiveness to mu opioid agonists such …

Rationale: Recent studies indicate that sex and rodent strain are determinants of sensitivity
to opioid-induced antinociception. Objectives: The present study examined the influence of …

Sex differences have been observed in the antinociceptive effects of opioids in rodents and
rhesus monkeys. Sex differences in the affinity of opioid ligands for opioid receptors may …

Aim: To evaluate the effect of single administrations of asimadoline, a κ‐opioid agonist, on
satiation volume, postprandial symptoms and gastric volumes. Methods: Healthy subjects …

Background Asimadoline, a kappa‐opioid agonist, reduces visceral sensitivity in
experimental animal models and may decrease satiation and postprandial fullness in …

Several studies have supported that N-methyl-D-aspartate receptor antagonist can reduce
the perception of postoperative pain. Hormonal fluctuations throughout the human menstrual …