During pregnancy, the maternal uterus and fetus form a special microenvironment at the
maternal-fetal interface to support fetal development. Extravillous trophoblasts (EVTs) …

Objective Primary studies and systematic reviews provide estimates of varying accuracy for
different factors in the prediction of pre‐eclampsia. The aim of this study was to review …

Preeclampsia is a condition associated with high rates of maternal-fetal morbidity and
mortality. It usually occurs in 3–10% of nulliparous women and 18% of previously affected …

The HLA class Ib genes, HLA-E, HLA-F, and HLA-G, were discovered long after the classical
HLA class Ia genes. The elucidation of their functions had a modest beginning. However …

Background HLA-G is an immune checkpoint molecule. Since a differential molecule
expression has been reported even for healthy individuals, many studies have focused on …

Preeclampsia is a pregnancy-induced hypertensive disorder, the pathophysiology of which
includes underlying maternal cardiovascular disease, deficient spiral artery remodeling …

Placental vascularization is a tightly regulated physiological process in which the maternal
immune system plays a fundamental role. Vascularization of the maternal-placental interface …

The non-classical HLA class I molecule HLA-G is expressed in trophoblasts where it
contributes to maternal-fetal tolerance. HLA-G has been implicated in the control of …

Background: Preeclampsia (PE) is a multisystem syndrome that is a primary source of fetal–
maternal morbidity and mortality. Human leukocyte antigen-G (HLA-G) is a nonclassical …

Pre-existing diabetes, hypertension and kidney disorders are prominent risk factors of pre-
eclampsia (PE). It is a multifactorial pregnancy disorder associated with high blood pressure …