Cells rely on the endoplasmic reticulum (ER) to fold and assemble newly synthesized
transmembrane and secretory proteins—essential for cellular structure–function and for both …

Organisms are constantly exposed to stress both from the external environment and
internally within the cell. To maintain cellular homeostasis under different environmental and …

Introduction: The primary objective of researchers in the biology of aging is to gain a
comprehensive understanding of the aging process while developing practical solutions that …

Microbial infectivity increases with rising environmental temperature, heightening the risk of
infection to host organisms. The host's basal immunity is activated accordingly to mitigate …

Cold affects many aspects of biology, medicine, agriculture, and industry. Here, we identify a
conserved endoplasmic reticulum (ER) stress response, distinct from the canonical unfolded …

Animals constantly encounter environmental and physiological stressors that threaten
survival and fertility. Somatic stress responses and germ cell arrest/repair mechanisms are …

The proteome of a cell helps to define its functional specialization. Most proteins must be
translated and properly folded to ensure their biological function, but with aging, animals …

Environmental conditions experienced early in the life of an animal can result in gene
expression changes later in its life history. We have previously shown that C. elegans …

Xbp1 splicing and regulated IRE1-dependent RNA decay (RIDD) are two RNase activities of
the ER stress sensor IRE1. While Xbp1 splicing has important roles in stress responses and …

Sex-specific behaviors within a species are often attributed to variances in neuronal wiring
and molecular signatures. However, how the genetic sex shapes the molecular architecture …