Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …

Herpes simplex virus type 1 is a neurotropic herpesvirus that establishes latency within
sensory neurones. Following primary infection, the virus replicates productively within …

Latent HIV proviruses are silenced as the result of deacetylation and methylation of histones
located at the viral long terminal repeat (LTR). Inhibition of histone deacetylases (HDACs) …

Herpes simplex virus (HSV) evolved an elegant strategy that enables the virus to impact a
large fraction of the human population. The virus replicates at the portal of entry (mouth …

Herpes simplex virus type 1 (HSV-1; human herpesvirus 1) and varicella-zoster virus (VZV;
human herpesvirus 3) are human neurotropic alphaherpesviruses that cause lifelong …

Herpes simplex virus (HSV) establishes a latent infection in peripheral neurons and can
periodically reactivate to cause disease. Reactivation can be triggered by a variety of stimuli …

Viral latency can be considered a metastable, nonproductive infection state that is capable
of subsequent reactivation to repeat the infection cycle. Viral latent infections have …

Epigenetic modifications of the herpesviral genome play a key role in the transcriptional
control of latent and lytic genes during a productive viral lifecycle. In this study, we describe …

Herpesvirus latency is generally thought to be governed by epigenetic modifications, but the
dynamics of viral chromatin at early timepoints of latent infection are poorly understood …

Herpes simplex virus (HSV) reactivation from latent neuronal infection requires stimulation of
lytic gene expression from promoters associated with repressive heterochromatin. Various …