Virus-like particles (VLPs) are multiprotein structures that mimic the organization and
conformation of authentic native viruses but lack the viral genome, potentially yielding safer …

Compared to traditional chromatography using resins in packed-bed columns, membrane
chromatography is a relatively new and immature bioseparation technology based on the …

Insect-derived baculoviruses have emerged as versatile and safe workhorses of
biotechnology. Baculovirus expression vectors (BEVs) have been applied widely for crop …

The baculovirus‐insect cell expression system is widely used in producing recombinant
proteins. This review is focused on the use of this expression system in developing …

Virus-like particles (VLPs) are self-assembled structures derived from viral antigens that
mimic the native architecture of viruses but lack the viral genome. VLPs have emerged as a …

Affinity chromatography is among the most powerful separation techniques, achieving the
finest separation with high yields even in the most challenging feed streams. Incorporating …

Separation of enveloped virus-like particles from other extracellular vesicles is a challenging
separation problem due to the similarity of these bionanoparticles. Without simple and …

The downstream processing of virus particles for vaccination or gene therapy is becoming a
critical bottleneck as upstream titers keep improving. Moreover, the growing pressure to …

Baculovirus and insect cell culture technologies have mostly been limited to research
laboratories for the transient expression of target proteins for drug development purposes …

Baculovirus infects insects in nature and is non-pathogenic to humans, but can transduce a
broad range of mammalian and avian cells. Thanks to the biosafety, large cloning capacity …