Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. One of the major
clinical challenges is adequate diagnosis and treatment of central nervous system (CNS) …

Acute leukemias (both myeloid and lymphoblastic) are a group of diseases for which each
year more successful therapies are implemented. However, in a subset of cases the overall …

Chimeric antigen receptor-modified (CAR) T cells targeting CD19 (CART19) have shown
therapeutical activities in CD19+ malignancies. However, the etiological nature of …

COI notes: NP: Consulting/honorarium: AbbVie; Celgene; Stemline; Incyte; Novartis;
MustangBio; Roche Diagnostics, LFB, Sanofi, ImmunoGen; Research funding/clinical trials …

Chimeric antigen receptor (CAR) T-cell systemic immunotherapy has revolutionized how
clinicians treat several refractory and relapsed hematologic malignancies. Due to its peculiar …

Acute lymphocytic leukemia (ALL) is the most frequent form of all childhood leukemias,
mostly affecting children between 2 and 4 years old. Oral symptoms, such as mouth ulcers …

PURPOSE This study (Childrens Cancer Group [CCG]-105) was designed in part to
determine in a prospective randomized trial whether intrathecal methotrexate (IT MTX) …

Acute leukemia is a highly heterogeneous disease; therefore, combination therapy is
commonly used for patient treatment. Drug–drug interaction is a major concern of combined …

Simple Summary The improved understanding of acute lymphoblastic leukemia has brought
with it several new therapy strategies as well as novel treatment agents. The aim of our …

Background Usually, central nervous system (CNS) involvement in acute lymphoblastic
leukemia (ALL) is diagnosed by cytomorphology (CM) of cerebrospinal fluid (CSF) on …