[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation

NA Trayanova, A Lyon, J Shade… - Physiological …, 2023 - pmc.ncbi.nlm.nih.gov
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

The 'Digital Twin'to enable the vision of precision cardiology

J Corral-Acero, F Margara, M Marciniak… - European heart …, 2020 - academic.oup.com
Providing therapies tailored to each patient is the vision of precision medicine, enabled by
the increasing ability to capture extensive data about individual patients. In this position …

Creation and application of virtual patient cohorts of heart models

SA Niederer, Y Aboelkassem… - … of the Royal …, 2020 - royalsocietypublishing.org
Patient-specific cardiac models are now being used to guide therapies. The increased use
of patient-specific cardiac simulations in clinical care will give rise to the development of …

[HTML][HTML] The role of mechano-electric feedbacks and hemodynamic coupling in scar-related ventricular tachycardia

M Salvador, F Regazzoni, S Pagani… - Computers in Biology …, 2022 - Elsevier
Abstract Mechano-electric feedbacks (MEFs), which model how mechanical stimuli are
transduced into electrical signals, have received sparse investigation by considering …

[HTML][HTML] Computer modeling of radiofrequency cardiac ablation: 30 years of bioengineering research

A González-Suárez, JJ Pérez, RM Irastorza… - Computer Methods and …, 2022 - Elsevier
This review begins with a rationale of the importance of theoretical, mathematical and
computational models for radiofrequency (RF) catheter ablation (RFCA). We then describe …

Whole-heart ventricular arrhythmia modeling moving forward: Mechanistic insights and translational applications

E Sung, S Etoz, Y Zhang, NA Trayanova - Biophysics reviews, 2021 - pubs.aip.org
Ventricular arrhythmias are the primary cause of sudden cardiac death and one of the
leading causes of mortality worldwide. Whole-heart computational modeling offers a unique …

An automata-based cardiac electrophysiology simulator to assess arrhythmia inducibility

D Serra, P Romero, I Garcia-Fernandez, M Lozano… - Mathematics, 2022 - mdpi.com
Personalized cardiac electrophysiology simulations have demonstrated great potential to
study cardiac arrhythmias and help in therapy planning of radio-frequency ablation. Its …

Cobiveco: Consistent biventricular coordinates for precise and intuitive description of position in the heart–with matlab implementation

S Schuler, N Pilia, D Potyagaylo, A Loewe - Medical Image Analysis, 2021 - Elsevier
Ventricular coordinates are widely used as a versatile tool for various applications that
benefit from a description of local position within the heart. However, the practical usefulness …

Building Digital Twins for Cardiovascular Health: From Principles to Clinical Impact

K Sel, D Osman, F Zare… - Journal of the …, 2024 - ahajournals.org
The past several decades have seen rapid advances in diagnosis and treatment of
cardiovascular diseases and stroke, enabled by technological breakthroughs in imaging …

[HTML][HTML] An automated near-real time computational method for induction and treatment of scar-related ventricular tachycardias

FO Campos, A Neic, CM Costa, J Whitaker… - Medical Image …, 2022 - Elsevier
Catheter ablation is currently the only curative treatment for scar-related ventricular
tachycardias (VTs). However, not only are ablation procedures long, with relatively high risk …