Background Over 120 million mice and rats are used annually in research, conventionally
housed in shoebox-sized cages that restrict natural behaviours (eg nesting and burrowing) …

Aging entails a progressive decline of cognitive abilities. However, since the brain is
endowed with considerable plasticity, adequate stimulation can delay or partially …

This review describes the role of social isolation in the development of anxiety and
depression-like behavior in rodents. The duration of social isolation, age from onset of social …

Social play is a dynamic and rewarding behavior abundantly expressed by most mammals
during the juvenile period. While its exact function is debated, various rodent studies on the …

Alcohol use disorder (AUD) is a debilitating psychiatric disorder characterized by drinking
despite negative social and biological consequences. AUDs make up 71% of substance use …

Social isolation is a reliable method used for the induction of depression and psychiatric
disorders in rodents. It has been suggested that social isolation can lead to …

Chronic social stress is a significant risk factor for several neuropsychiatric disorders, mainly
major depressive disorder (MDD). In this way, patients with clinical depression may display …

Bipolar disorder (BD) is a chronic mood disorder characterized by manic and depressive
episodes. Dysregulation of neuroplasticity and calcium homeostasis are frequently observed …

Instant cascara (IC) is a sustainable beverage obtained from dried coffee cherry pulp, rich in
nutrients and bioactive compounds. The present research aimed to determine the effects of …

Objective During the COVID‐19 pandemic, quarantine and staying at home is advised. The
social relationship between people has become deficient, and human social isolation (SI) …