The endoplasmic reticulum (ER) functions as a quality-control organelle for protein
homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated …

Melanomas arising in the uveal tract of the eye are a rare form of the disease with a biology
and clinical phenotype distinct from their more common cutaneous counterparts. Treatment …

PURPOSE Metastatic uveal melanoma has poor overall survival (OS) and no approved
systemic therapy options. Studies of single-agent immunotherapy regimens have shown …

Abstract Treatment of primary intraocular uveal melanoma has developed considerably, its
driver genes are largely unraveled, and the ways to assess its risk for metastases are very …

Uveal melanoma (UM) is the most common intraocular malignancy and arises from
melanocytes in the iris, ciliary body, or choroid. Early diagnosis and local treatment is …

Background Despite the completion of numerous phase II studies, a standard of care
treatment has yet to be defined for metastatic uveal melanoma (mUM). To determine …

BACKGROUND Antibodies inhibiting the programmed death receptor 1 (PD‐1) have
demonstrated significant activity in the treatment of advanced cutaneous melanoma. The …

Importance Uveal melanoma is characterized by mutations inGNAQandGNA11, resulting in
mitogen-activated protein kinase pathway activation. Objective To assess the efficacy of …

Uveal melanoma is the most common primary malignant tumor of the eye in adults,
predominantly found in Caucasians. Local tumor control of uveal melanoma is excellent, yet …

Uveal melanoma (UM), a rare cancer of the eye, is distinct from cutaneous melanoma by its
etiology, the mutation frequency and profile, and its clinical behavior including resistance to …