The cellular response to external stress signals and DNA damage depends on the activity of
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis …

Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …

The histone H3K36 methyltransferase SETD2 is frequently mutated or deleted in a variety of
human tumors. Nevertheless, the role of SETD2 loss in oncogenesis remains largely …

Enormous efforts have been made to target metabolic dependencies of cancer cells for
developing new therapies. However, the therapeutic efficacy of glycolysis inhibitors is limited …

The intestinal stem cell (ISC) marker LGR5 is a receptor for R‐spondin (RSPO) that functions
to potentiate Wnt signalling in the proliferating crypt. It has been recently shown that Wnt …

HUWE1 is a large, enigmatic HECT-domain ubiquitin ligase implicated in the regulation of
diverse pathways, including DNA repair, apoptosis, and differentiation. How HUWE1 …

Initially described as lytic bodies due to their degradative and recycling functions, lysosomes
play a critical role in metabolic adaptation to nutrient availability. More recently, the …

Cancer genome sequencing projects have identified hundreds of genetic alterations, often
at low frequencies, raising questions as to their functional relevance. One exemplar gene is …

Emerging evidence indicates the role of cancer stem cells (CSCs) in tumor relapse and
therapeutic resistance in patients with hepatocellular carcinoma (HCC). To identify novel …

The EPH/ephrin system constitutes a bidirectional signaling pathway comprised of a family
of tyrosine kinase receptors in tandem with their plasma membrane-bound ligand (ephrins) …