Oxidative stress during HIV infection: mechanisms and consequences

AV Ivanov, VT Valuev-Elliston… - Oxidative medicine …, 2016 - Wiley Online Library
It is generally acknowledged that reactive oxygen species (ROS) play crucial roles in a
variety of natural processes in cells. If increased to levels which cannot be neutralized by the …

Redox-modulating agents in the treatment of viral infections

P Checconi, M De Angelis, ME Marcocci… - International Journal of …, 2020 - mdpi.com
Viruses use cell machinery to replicate their genome and produce viral proteins. For this
reason, several intracellular factors, including the redox state, might directly or indirectly …

Intracellular redox-modulated pathways as targets for effective approaches in the treatment of viral infection

A Fraternale, C Zara, M De Angelis, L Nencioni… - International Journal of …, 2021 - mdpi.com
Host-directed therapy using drugs that target cellular pathways required for virus lifecycle or
its clearance might represent an effective approach for treating infectious diseases …

Glutathione induced immune-stimulatory activity by promoting M1-like macrophages polarization via potential ROS scavenging capacity

DH Kwon, H Lee, C Park, SH Hong, SH Hong, GY Kim… - Antioxidants, 2019 - mdpi.com
The present study investigated the immunomodulatory activity of reduced glutathione (GSH)
by assessment of the macrophage polarization (MP)-mediated immune response in RAW …

[HTML][HTML] S-glutathionylation, friend or foe in cardiovascular health and disease

NA Rashdan, B Shrestha, CB Pattillo - Redox Biology, 2020 - Elsevier
Glutathione is a low molecular weight thiol that is present at high levels in the cell. The high
levels of glutathione in the cell make it one of the most abundant antioxidants contributing to …

The influence of redox modulation on hypoxic endothelial cell metabolic and proteomic profiles through a small thiol‐based compound tuning glutathione and …

M Bruschi, F Biancucci, S Masini, F Piacente, D Ligi… - Biofactors, 2023 - Wiley Online Library
Reduction in oxygen levels is a key feature in the physiology of the bone marrow (BM) niche
where hematopoiesis occurs. The BM niche is a highly vascularized tissue and endothelial …

[HTML][HTML] Glutathione increase by the n‐butanoyl glutathione derivative (GSH‐C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice …

D Amatore, I Celestino, S Brundu, L Galluzzi… - FASEB …, 2019 - ncbi.nlm.nih.gov
During aging, glutathione (GSH) content declines and the immune system undergoes a
deficiency in the induction of Th1 response. Reduced secretion of Th1 cytokines, which is …

Organic afterglow nanoparticles in bioapplications

H Shen, S Liao, Z Li, Y Wang, S Huan… - … A European Journal, 2023 - Wiley Online Library
Organic afterglow nanoparticles are unique optical materials that emit light long after
cessation of excitation. Due to their advantages of no need for real‐time light excitation …

The role of glutathione in the management of cell-mediated immune responses in individuals with HIV

N Lin, T Erdos, C Louie, R Desai, N Lin… - International Journal of …, 2024 - mdpi.com
Human immunodeficiency virus (HIV) is a major cause of death worldwide. Without
appropriate antiretroviral therapy, the infection can develop into acquired immunodeficiency …

[HTML][HTML] Calcium signals between the ryanodine receptor-and mitochondria critically regulate the effects of arsenite on mitochondrial superoxide formation and on the …

A Guidarelli, M Fiorani, L Cerioni, O Cantoni - Redox biology, 2019 - Elsevier
A low concentration of arsenite (6 h), selectively stimulating the intraluminal crosstalk
between the inositol-1, 4, 5-triphosphate receptor and the ryanodine receptor (RyR) …