The association of COVID-19 severity and susceptibility and genetic risk factors: A systematic review of the literature

A Ishak, M Mehendale, MM AlRawashdeh… - Gene, 2022 - Elsevier
Background COVID-19 is associated with several risk factors such as distinct ethnicities
(genetic ancestry), races, sexes, age, pre-existing comorbidities, smoking, and genetics. The …

The prevalence and impact of coinfection and superinfection on the severity and outcome of COVID-19 infection: an updated literature review

SA Omoush, JAM Alzyoud - Pathogens, 2022 - mdpi.com
Patients with viral illness are at higher risk of secondary infections—whether bacterial, viral,
or parasitic—that usually lead to a worse prognosis. In the setting of Corona Virus Disease …

ACE and ACE2 Gene Variants Are Associated With Severe Outcomes of COVID-19 in Men

LE Martinez-Gomez, B Herrera-Lopez… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the
current coronavirus disease 2019 (COVID-19) pandemic, affecting more than 219 countries …

[HTML][HTML] Potential genes associated with COVID-19 and comorbidity

S Feng, F Song, W Guo, J Tan, X Zhang… - … journal of medical …, 2022 - ncbi.nlm.nih.gov
Hypertension, diabetes mellitus, and coronary artery disease are common comorbidities and
dangerous factors for infection and serious COVID-19. Polymorphisms in genes associated …

[HTML][HTML] A common TMPRSS2 variant has a protective effect against severe COVID-19

A David, N Parkinson, TP Peacock… - Current research in …, 2022 - Elsevier
Background: The human protein transmembrane protease serine type 2 (TMPRSS2) plays a
key role in SARS-CoV-2 infection, as it is required to activate the virus' spike protein …

Dynamics of SARS-CoV-2 major genetic lineages in Moscow in the context of vaccine prophylaxis

VA Gushchin, AA Pochtovyi, DD Kustova… - International Journal of …, 2022 - mdpi.com
Findings collected over two and a half years of the COVID-19 pandemic demonstrated that
the level immunity resulting from vaccination and infection is insufficient to stop the …

Plasma proteomic variables related to COVID-19 severity: an untargeted nLC-MS/MS investigation

L Pagani, C Chinello, G Risca, G Capitoli… - International Journal of …, 2023 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection leads to a wide
range of clinical manifestations and determines the need for personalized and precision …

Polymorphisms and mutations of ACE2 and TMPRSS2 genes are associated with COVID-19: a systematic review

J Li, Y Wang, Y Liu, Z Zhang, Y Zhai, Y Dai… - European Journal of …, 2022 - Springer
Objective To determine the effect of polymorphisms and mutations in angiotensin-converting
enzyme 2 (ACE2) and Type 2 transmembrane serine proteases (TMPRSS2) genes on …

Impact of interferon-induced transmembrane protein 3 gene rs12252 polymorphism on COVID-19 mortality

I Ahmadi, A Afifipour, F Sakhaee, MS Zamani… - Cytokine, 2022 - Elsevier
Background and aims Interferon-induced transmembrane protein 3 (IFITM3) plays a critical
role in the adaptive and innate immune response by preventing membrane hemifusion …

Clinical features related to severity and mortality among COVID-19 patients in a pre-vaccine period in Luanda, Angola

CS Sebastiao, A Cogle, ADA Teixeira… - Tropical Medicine and …, 2022 - mdpi.com
Background: Infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) is associated with clinical features of diverse severity. Few studies investigated the …