Optical techniques have revolutionized the investigation of cardiac cellular physiology and
advanced our understanding of basic mechanisms of electrical activity, calcium …

Defibrillation shocks are commonly used to terminate life-threatening arrhythmias. According
to the excitation theory of defibrillation, such shocks are aimed at depolarizing the …

The response of the heart to electrical shock, electrical propagation in sinus rhythm, and the
spatiotemporal dynamics of ventricular fibrillation all depend critically on the electrical …

This paper presents methods to build histo-anatomically detailed individualized cardiac
models. The models are based on high-resolution three-dimensional anatomical and/or …

Significant advancements in imaging technology and the dramatic increase in computer
power over the last few years broke the ground for the construction of anatomically realistic …

Computational models have become a fundamental tool in cardiac research. Models are
evolving to cover multiple scales and physical mechanisms. They are moving towards …

Electrical shock has been the one effective treatment for ventricular fibrillation for several
decades. With the advancement of electrical and optical mapping techniques, histology, and …

Aims c-Jun N-terminal kinase (JNK) activation is implicated in cardiovascular diseases and
ageing, which are linked to enhanced propensity to atrial fibrillation (AF). However, the …

Fast voltage-sensitive dyes are widely used to image cardiac electrical activity. Typically, the
emission spectrum of these fluorochromes is wavelength shifted with altered membrane …

Voltage-sensitive fluorescent dyes are commonly used to measure cardiac electrical activity.
Recent studies indicate, however, that optical action potentials (OAPs) recorded from the …