Summary Cyclic GMP-AMP synthase (cGAS) is the major sensor for cytosolic DNA and
activates type I interferon signaling and plays an essential role in antitumor immunity …

All animals have evolved solutions to manage their genomes, enabling the efficient
organization of meters of DNA strands in the nucleus and allowing for nuanced regulation of …

Since the turn of the century, advances in targeted therapy and immunotherapy have
revolutionized the treatment of cancer. Although these approaches have far outperformed …

Existing evidence demonstrates that coronavirus disease 2019 (COVID-19) leads to
psychiatric illness, despite its main clinical manifestations affecting the respiratory system …

Background Epigenetic regulatory mechanisms are divergent across the animal kingdom,
yet these mechanisms are not well studied in non-model organisms. Unique features of …

While epigenetic mechanisms such as DNA methylation and histone modification are known
to be important for gene suppression, relatively little is still understood about the interplay …

The impacts of exposure to the pervasive environmental toxicant, inorganic arsenic (iAs), on
human and fish health are well characterized and several lines of evidence suggest that …

Coordinating epigenomic inheritance and cell cycle progression is essential for
organogenesis. UHRF1 connects these functions during development by facilitating …

The histone variant H2A. Z is central to early embryonic development, determining
transcriptional competency through chromatin regulation of gene promoters and enhancers …

Cancer stem cells (CSCs) contribute to tumor initiation, progression, and recurrence in many
types of cancer, including hepatocellular carcinoma (HCC). Epigenetic reprogramming of …