[HTML][HTML] Human D-amino acid oxidase: structure, function, and regulation
D-Amino acid oxidase (DAAO) is an FAD-containing flavoenzyme that catalyzes with
absolute stereoselectivity the oxidative deamination of all natural D-amino acids, the only …
absolute stereoselectivity the oxidative deamination of all natural D-amino acids, the only …
[HTML][HTML] Biochemical properties of human D-amino acid oxidase variants and their potential significance in pathologies
The stereoselective flavoenzyme D-amino acid oxidase (DAAO) catalyzes the oxidative
deamination of neutral and polar D-amino acids producing the corresponding α-keto acids …
deamination of neutral and polar D-amino acids producing the corresponding α-keto acids …
Molecular dynamics simulations: principles, methods, and applications in protein conformational dynamics
AK Padhi, M Janežič, KYJ Zhang - Advances in protein molecular and …, 2022 - Elsevier
Molecular dynamics (MD) is a powerful computational technique that allows us to simulate
the interactions of atoms and molecules of a system over a specific period of time through …
the interactions of atoms and molecules of a system over a specific period of time through …
Characterization of E121K mutation of D-amino acid oxidase–insights into mechanisms leading to amyotrophic lateral sclerosis
D-amino acid oxidase (DAO) maintains the intracellular d-serine level which modulates the
activity of the N-methyl-d-aspartate receptor and its dysfunction has been linked to several …
activity of the N-methyl-d-aspartate receptor and its dysfunction has been linked to several …
[HTML][HTML] Focus on the role of d-serine and d-amino acid oxidase in amyotrophic lateral sclerosis/motor neuron disease (ALS)
NR Kondori, P Paul, JP Robbins, K Liu… - Frontiers in molecular …, 2018 - frontiersin.org
We have investigated a pathogenic mutation in D-amino acid oxidase (DAO), DAOR199W,
associated with familial Amyotrophic Lateral Sclerosis (ALS) that impairs D-serine …
associated with familial Amyotrophic Lateral Sclerosis (ALS) that impairs D-serine …
[图书][B] Biological chirality
G Palyi - 2019 - books.google.com
Biological Chirality describes this occurrence, its history, and early research around the
topic. The work covers analytical methods for observing the phenomenon, providing current …
topic. The work covers analytical methods for observing the phenomenon, providing current …
Gut Symptoms, Gut Dysbiosis and Gut-Derived Toxins in ALS
A Lee, R Henderson, J Aylward… - International Journal of …, 2024 - mdpi.com
Many pathogenetic mechanisms have been proposed for amyotrophic lateral sclerosis
(ALS). Recently, there have been emerging suggestions of a possible role for the gut …
(ALS). Recently, there have been emerging suggestions of a possible role for the gut …
[HTML][HTML] Mechanistic insights into the loss-of-function mechanisms of rare human D-amino acid oxidase variants implicated in amyotrophic lateral sclerosis
AK Padhi, KYJ Zhang - Scientific Reports, 2020 - nature.com
Impaired enzymatic activity in D-amino acid oxidase (DAAO) caused by missense mutations
has been shown to trigger amyotrophic lateral sclerosis (ALS) through an abnormal …
has been shown to trigger amyotrophic lateral sclerosis (ALS) through an abnormal …
Aggregation of E121K mutant D-amino acid oxidase and ubiquitination-mediated autophagy mechanisms leading to amyotrophic lateral sclerosis
Abstract Amyotrophic Lateral Sclerosis (ALS) is a terminal adult-onset neuromuscular
disorder. Our group has been studying this illness and previously reported novel mutations …
disorder. Our group has been studying this illness and previously reported novel mutations …
Altered synaptic plasticity: plausible mechanisms associated with viral infections
Neurotropic viruses target the central nervous system through various mechanisms: they
have the potential to modulate synaptic plasticity, causing cognitive impairments by blocking …
have the potential to modulate synaptic plasticity, causing cognitive impairments by blocking …