Siderophores are chelators with extremely strong affinity for ferric iron and are best known
for their capacity to feed microorganisms with this metal. Despite their preference for iron …

Transition metals are both essential to enzymatic catalysis and limited in environmental
availability. These two biological facts have together driven organisms to evolve …

Urease, the first enzyme to be crystallized, contains a dinuclear nickel metallocenter that
catalyzes the decomposition of urea to produce ammonia, a reaction of great agricultural …

Nickel is an essential catalytic cofactor of enzymes found in eubacteria, archaebacteria,
fungi, and plants. 1-6 These enzymes catalyze a diverse array of reactions that include both …

Bacterial transition metal homoeostasis or simply 'metallostasis' describes the process by
which cells control the intracellular availability of functionally required metal cofactors, from …

This review focuses on the impact of nickel on human health. In particular, the dual nature of
nickel as an essential as well as toxic element in nature is described, and the main forms of …

Isothermal titration calorimetry (ITC) is a fast, accurate and label‐free method for measuring
the thermodynamics and binding affinities of molecular associations in solution. Because the …

Bacterial pathogens employ a general strategy to overcome host defenses by coordinating
the virulence gene expression using dedicated regulatory systems that could raise intricate …

Nickel homeostasis is important for pathogenic and ureolytic bacteria, which use this metal
ion as enzymatic cofactor. For example, in the human pathogen Helicobacter pylori an …

The ability of Helicobacter pylori, one of the most successful human bacterial pathogens, to
colonize the acidic gastric niche persistently, depends on the proper homeostasis of …