Blood vessel endothelial cells (ECs) have long been known to modulate inflammation by
regulating immune cell trafficking, activation status and function. However, whether the …

Senescence compromises the essential role that the endothelium plays in maintaining
vascular homeostasis, so promoting endothelial dysfunction and the development of age …

Estrogen is a potent steroid with pleiotropic effects, which have yet to be fully elucidated.
Estrogen has both nuclear and non-nuclear effects. The rapid response to estrogen, which …

Antigen presentation by cells of the vessel wall may initiate rapid and localized memory
immune responses in peripheral tissues. Peptide antigens displayed on major …

Tumors can escape immunity through multiple mechanisms, one of which is by enforcing a
state of unresponsiveness of the tumor vasculature to inflammatory cytokines. This results in …

Dendritic cells (DCs) are central to T cell immunity, and many strategies have been used to
manipulate DCs to modify immune responses. We investigated the effects of antioxidants …

Circulating T cells contact blood vessels either when they extravasate across the walls of
microvessels into inflamed tissues or when they enter into the walls of larger vessels in …

Microvascular leakage due to endothelial barrier dysfunction is a prominent feature of T
helper 2 (Th2) cytokine mediated allergic inflammation. Interleukin-4 (IL-4) is a potent Th2 …

Genetic modification of dendritic-cell (DC) function is an attractive approach to treat disease,
either using mature DCs (mDCs) to immunize patients, or immature DCs (iDCs) to induce …

Cell surface coating is a methodology wherein specific molecules are transiently anchored
onto cell membrane to modulate cell behavior. Cell surface coating was tested as a method …