ERK signalling: a master regulator of cell behaviour, life and fate
H Lavoie, J Gagnon, M Therrien - Nature reviews Molecular cell biology, 2020 - nature.com
The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream
components of a phosphorelay pathway that conveys growth and mitogenic signals largely …
components of a phosphorelay pathway that conveys growth and mitogenic signals largely …
Activin/Nodal signalling in stem cells
S Pauklin, L Vallier - Development, 2015 - journals.biologists.com
Activin/Nodal growth factors control a broad range of biological processes, including early
cell fate decisions, organogenesis and adult tissue homeostasis. Here, we provide an …
cell fate decisions, organogenesis and adult tissue homeostasis. Here, we provide an …
[HTML][HTML] Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast
Human embryonic stem cells (hESCs) are derived from the inner cell mass of the blastocyst.
Despite sharing the common property of pluripotency, hESCs are notably distinct from …
Despite sharing the common property of pluripotency, hESCs are notably distinct from …
MEK inhibition induces MYOG and remodels super-enhancers in RAS-driven rhabdomyosarcoma
The RAS isoforms are frequently mutated in many types of human cancers, including
PAX3/PAX7 fusion-negative rhabdomyosarcoma. Pediatric RMS arises from skeletal muscle …
PAX3/PAX7 fusion-negative rhabdomyosarcoma. Pediatric RMS arises from skeletal muscle …
[HTML][HTML] Erk1/2 activity promotes chromatin features and RNAPII phosphorylation at developmental promoters in mouse ESCs
Erk1/2 activation contributes to mouse ES cell pluripotency. We found a direct role of Erk1/2
in modulating chromatin features required for regulated developmental gene expression …
in modulating chromatin features required for regulated developmental gene expression …
Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells
H Chen, R Guo, Q Zhang, H Guo… - Proceedings of the …, 2015 - National Acad Sciences
Inhibition of Mek/Erk signaling by pharmacological Mek inhibitors promotes self-renewal and
pluripotency of mouse embryonic stem cells (ESCs). Intriguingly, Erk signaling is essential …
pluripotency of mouse embryonic stem cells (ESCs). Intriguingly, Erk signaling is essential …
[HTML][HTML] A non-canonical BCOR-PRC1. 1 complex represses differentiation programs in human ESCs
Z Wang, MD Gearhart, YW Lee, I Kumar, B Ramazanov… - Cell stem cell, 2018 - cell.com
Polycomb group proteins regulate self-renewal and differentiation in many stem cell
systems. When assembled into two canonical complexes, PRC1 and PRC2, they …
systems. When assembled into two canonical complexes, PRC1 and PRC2, they …
Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells
Multiple myeloma (MM) is characterized by a highly unstable genome, with aneuploidy
observed in nearly all patients. The mechanism causing this karyotypic instability is largely …
observed in nearly all patients. The mechanism causing this karyotypic instability is largely …
[HTML][HTML] Navigating the ERK1/2 MAPK cascade
A Martin-Vega, MH Cobb - Biomolecules, 2023 - mdpi.com
The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological
processes including proliferation, cell cycle control, growth, and survival; common across all …
processes including proliferation, cell cycle control, growth, and survival; common across all …
HMMR maintains the stemness and tumorigenicity of glioblastoma stem-like cells
Glioblastoma (GBM) stem cells (GSC) are a subpopulation of tumor cells that display stem-
like characteristics (stemness) and play unique roles in tumor propagation, therapeutic …
like characteristics (stemness) and play unique roles in tumor propagation, therapeutic …