For three-quarters of a century, developmental biologists have been asking how the nervous
system is specified as distinct from the rest of the ectoderm during early development, and …

The forebrain, or prosencephalon, consists of the diencephalon and the telencephalon. The
diencephalon is the conduit for ascending sensory information, whereas the telencephalon …

During gastrulation, a cascade of inductive tissue interactions converts pre-existing polarity
in the mammalian embryo into antero-posterior pattern. This process is triggered by Nodal, a …

This book provides a comprehensive overview of the development of the human central
nervous system (CNS) in the context of its many developmental disorders due to genetic …

The LIM domain-binding protein 1 (Ldb1) is found in multi-protein complexes containing
various combinations of LIM-homeodomain, LIM-only, bHLH, GATA and Otx transcription …

The roles of extra-embryonic tissues in early vertebrate body patterning have been
extensively studied, yet we know little about their function during later developmental events …

The yolk syncytial layer (YSL) of the teleostean yolk cell is known to play important roles in
the induction of cellular mesendoderm, as well as the patterning of dorsal tissues. To …

Prechordal mesendoderm is formed in response to Nodal and maternal β-Catenin signaling
and is regulated by signals from anterior endoderm and chordamesoderm. Prechordal …

During vertebrate development the dorsal gastrula or Spemann-Mangold organizer
orchestrates axis formation largely by limiting the ventralizing and posteriorizing activity of …

Historically, examinations of gnathostome skulls have indicated that for essentially the
entirety of their existence, jaws have been characterized by a high degree of fidelity to an …