Proteins are continuously affected by various intrinsic and extrinsic factors. Damaged
proteins influence several intracellular pathways and result in different disorders and …

The balance between synthesis and degradation is crucial to maintain cellular homeostasis
and different mechanisms are known to keep this balance. In this review, we will provide a …

Lipids, proteins and DNA in the central nervous system have a high sensitivity to oxidative
stress. Reactive oxygen species (ROS)-induced damage increases with aging, especially in …

The formation of disulfide bonds between cysteine residues occurs during the folding of
many proteins that enter the secretory pathway. As the polypeptide chain collapses …

The endoplasmic reticulum (ER) lumen is chemically complex and crowded with
polypeptides in different stages of assembly. ER quality control monitors chaperone-assisted …

Accumulating evidence indicates that endoplasmic reticulum (ER) stress and the
subsequent unfolded protein response (UPR) are involved in the pathogenesis of not only …

Proteome quality control (PQC) is critical for the maintenance of cellular functionality and it is
assured by the curating activity of the proteostasis network (PN). PN is constituted of several …

Alzheimer's disease (AD) is the most common neurodegenerative disease. Although a major
cause of AD is the accumulation of amyloid-β (Aβ) peptide that induces neuronal loss and …

Abstract Background Adult T-cell Leukemia/Lymphoma (ATLL) is a rapidly progressing type
of T-cell non-Hodgkin lymphoma that is developed after the infection by human T-cell …

Proteasome is a protein degradation complex that plays a major role in maintaining cellular
homeostasis. Despite extensive efforts to identify protein substrates that are degraded …