Evaluation of antimicrobial, anticholinesterase potential of indole derivatives and unexpectedly synthesized novel benzodiazine: characterization, DFT and Hirshfeld …
The pharmacological effectiveness of indoles, benzoxazepines and benzodiazepines
initiated our synthesis of indole fused benoxazepine/benzodiazepine heterocycles, along …
initiated our synthesis of indole fused benoxazepine/benzodiazepine heterocycles, along …
Recent Development in the Search for Epidermal Growth Factor Receptor (EGFR) Inhibitors based on the Indole Pharmacophore
S Mishra, A Sahu, A Kaur, M Kaur… - Current Topics in …, 2024 - benthamdirect.com
The signal transduction and cell proliferation are regulated by the epidermal growth factor
receptor. The proliferation of tumor cells, apoptosis, invasion, and angiogenesis is inhibited …
receptor. The proliferation of tumor cells, apoptosis, invasion, and angiogenesis is inhibited …
[HTML][HTML] Synthesis, in-silico studies, and biological evaluation of some novel 3-thiazolyl-indoles as CDK2–inhibitors
The essential enzyme cyclin-dependent kinase 2 (CDK2) is a promising target for anticancer
drug development due to its pivotal role in regulating the cell cycle. This study aimed to …
drug development due to its pivotal role in regulating the cell cycle. This study aimed to …
Design, synthesis, and biological evaluation of indole-2-carboxamides as potential multi-target antiproliferative agents
LH Al-Wahaibi, AF Mohammed, MH Abdelrahman… - Pharmaceuticals, 2023 - mdpi.com
A small set of indole-based derivatives, IV and Va–I, was designed and synthesized.
Compounds Va–i demonstrated promising antiproliferative activity, with GI50 values ranging …
Compounds Va–i demonstrated promising antiproliferative activity, with GI50 values ranging …