Dissemination of antimicrobial resistance in microbial ecosystems through horizontal gene transfer

CJH Von Wintersdorff, J Penders… - Frontiers in …, 2016 - frontiersin.org
The emergence and spread of antibiotic resistance among pathogenic bacteria has been a
rising problem for public health in recent decades. It is becoming increasingly recognized …

Good microbes, bad genes? The dissemination of antimicrobial resistance in the human microbiome

A Crits-Christoph, HA Hallowell, K Koutouvalis… - Gut …, 2022 - Taylor & Francis
ABSTRACT A global rise in antimicrobial resistance among pathogenic bacteria has proved
to be a major public health threat, with the rate of multidrug-resistant bacterial infections …

Wastewater treatment plant resistomes are shaped by bacterial composition, genetic exchange, and upregulated expression in the effluent microbiomes

F Ju, K Beck, X Yin, A Maccagnan… - The ISME …, 2019 - academic.oup.com
Wastewater treatment plants (WWTPs) are implicated as hotspots for the dissemination of
antibacterial resistance into the environment. However, the in situ processes governing …

Next-generation approaches to understand and combat the antibiotic resistome

TS Crofts, AJ Gasparrini, G Dantas - Nature Reviews Microbiology, 2017 - nature.com
Antibiotic resistance is a natural feature of diverse microbial ecosystems. Although recent
studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of …

Improved annotation of antibiotic resistance determinants reveals microbial resistomes cluster by ecology

MK Gibson, KJ Forsberg, G Dantas - The ISME journal, 2015 - academic.oup.com
Antibiotic resistance is a dire clinical problem with important ecological dimensions. While
antibiotic resistance in human pathogens continues to rise at alarming rates, the impact of …

[HTML][HTML] Application of metagenomics in the human gut microbiome

WL Wang, SY Xu, ZG Ren, L Tao… - World journal of …, 2015 - ncbi.nlm.nih.gov
There are more than 1000 microbial species living in the complex human intestine. The gut
microbial community plays an important role in protecting the host against pathogenic …

The soil resistome: a critical review on antibiotic resistance origins, ecology and dissemination potential in telluric bacteria

J Nesme, P Simonet - Environmental microbiology, 2015 - Wiley Online Library
Soil is a large reservoir of microbial diversity and the majority of antimicrobial compounds
used today in human and veterinary health care have been isolated from soil …

Recent advances in function-based metagenomic screening

TR Ngara, H Zhang - Genomics, proteomics and bioinformatics, 2018 - academic.oup.com
Metagenomes from uncultured microorganisms are rich resources for novel enzyme genes.
The methods used to screen the metagenomic libraries fall into two categories, which are …

High-throughput metagenomic technologies for complex microbial community analysis: open and closed formats

J Zhou, Z He, Y Yang, Y Deng, SG Tringe… - MBio, 2015 - Am Soc Microbiol
Understanding the structure, functions, activities and dynamics of microbial communities in
natural environments is one of the grand challenges of 21st century science. To address this …

The human microbiome as a reservoir of antimicrobial resistance

J Penders, EE Stobberingh, PHM Savelkoul… - Frontiers in …, 2013 - frontiersin.org
The gut microbiota is amongst the most densely populated microbial ecosystem on earth.
While the microbiome exerts numerous health beneficial functions, the high density of micro …