Robustness and evolvability
J Masel, MV Trotter - Trends in Genetics, 2010 - cell.com
Why isn't random variation always deleterious? Are there factors that sometimes make
adaptation easier? Biological systems are extraordinarily robust to perturbation by …
adaptation easier? Biological systems are extraordinarily robust to perturbation by …
Coarse-graining as a downward causation mechanism
JC Flack - … Transactions of the Royal Society A …, 2017 - royalsocietypublishing.org
Downward causation is the controversial idea that 'higher'levels of organization can causally
influence behaviour at 'lower'levels of organization. Here I propose that we can gain traction …
influence behaviour at 'lower'levels of organization. Here I propose that we can gain traction …
Clinically relevant mutations in core metabolic genes confer antibiotic resistance
Although metabolism plays an active role in antibiotic lethality, antibiotic resistance is
generally associated with drug target modification, enzymatic inactivation, and/or transport …
generally associated with drug target modification, enzymatic inactivation, and/or transport …
[图书][B] Arrival of the fittest: solving evolution's greatest puzzle
A Wagner - 2014 - books.google.com
“Natural selection can preserve innovations, but it cannot create them. Nature's many
innovations—some uncannily perfect—call for natural principles that accelerate life's ability …
innovations—some uncannily perfect—call for natural principles that accelerate life's ability …
Impact of gene expression noise on organismal fitness and the efficacy of natural selection
Z Wang, J Zhang - Proceedings of the National Academy of …, 2011 - National Acad Sciences
Gene expression noise is a universal phenomenon across all life forms. Although beneficial
under certain circumstances, expression noise is generally thought to be deleterious …
under certain circumstances, expression noise is generally thought to be deleterious …
The emergence and early evolution of biological carbon-fixation
R Braakman, E Smith - PLoS Computational Biology, 2012 - journals.plos.org
The fixation of into living matter sustains all life on Earth, and embeds the biosphere within
geochemistry. The six known chemical pathways used by extant organisms for this function …
geochemistry. The six known chemical pathways used by extant organisms for this function …
A latent capacity for evolutionary innovation through exaptation in metabolic systems
Some evolutionary innovations may originate non-adaptively as exaptations, or pre-
adaptations, which are by-products of other adaptive traits,,,,. Examples include feathers …
adaptations, which are by-products of other adaptive traits,,,,. Examples include feathers …
The players may change but the game remains: network analyses of ruminal microbiomes suggest taxonomic differences mask functional similarity
TM Taxis, S Wolff, SJ Gregg, NO Minton… - Nucleic acids …, 2015 - academic.oup.com
By mapping translated metagenomic reads to a microbial metabolic network, we show that
ruminal ecosystems that are rather dissimilar in their taxonomy can be considerably more …
ruminal ecosystems that are rather dissimilar in their taxonomy can be considerably more …
Growth temperature and genome size in bacteria are negatively correlated, suggesting genomic streamlining during thermal adaptation
Prokaryotic genomes are small and compact. Either this feature is caused by neutral
evolution or by natural selection favoring small genomes—genome streamlining. Three …
evolution or by natural selection favoring small genomes—genome streamlining. Three …
[HTML][HTML] From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics
Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …