While γδ T cells are present virtually in all vertebrates, there is a remarkable lack of
conservation of the TRG and TRD loci underlying the generation of the γδ T cell receptor …

The response of gamma delta (γδ) T cells in the acute versus chronic phases of the same
infection is unclear. How γδ T cells function in acute Mycobacterium tuberculosis (Mtb) …

During ontogeny, γδ T cells emerge from the thymus and directly seed peripheral tissues for
in situ immunity. However, their functional role in humans has largely been defined from …

Human CD1a is a non-polymorphic glycoprotein that presents lipid antigens to T cells. The
most obvious role of CD1a is associated with its expression on Langerhans cells in …

Plasmodium falciparum malaria drives immunoregulatory responses across multiple cell
subsets, which protects from immunopathogenesis, but also hampers the development of …

Summary γδ T cells are generally considered innate-like lymphocytes, however, an"
adaptive-like" γδ compartment has now emerged. To understand transcriptional regulation …

The function and phenotype of γδ T cells in the context of common variable
immunodeficiency (CVID) has not been explored. CVID is a primary immunodeficiency …

Although most SARS-CoV-2 infections are mild, some patients develop systemic
inflammation and progress to acute respiratory distress syndrome (ARDS). However, the …

Resistance to clinical malaria takes years to develop even in hyperendemic regions and
sterilizing immunity has rarely been observed. To evaluate the maturation of the host …

IgG antibodies are key effector molecules in acquired immunity to Plasmodium falciparum
malaria, and the PfEMP1 adhesins expressed on the surface of the infected erythrocytes are …