Mitochondria are essential in most eukaryotes and are involved in numerous biological
functions including ATP production, cofactor biosyntheses, apoptosis, lipid synthesis, and …

Mitochondria play a key role in iron metabolism in that they synthesize heme, assemble iron–
sulfur (Fe/S) proteins, and participate in cellular iron regulation. Here, we review the latter …

Iron-sulfur (Fe/S) proteins are involved in a wide variety of cellular processes such as
enzymatic reactions, respiration, cofactor biosynthesis, ribosome biogenesis, regulation of …

All living organisms require nutrient minerals for growth and have developed mechanisms to
acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment …

Work during the past 14 years has shown that mitochondria are the primary site for the
biosynthesis of iron–sulfur (Fe/S) clusters. In fact, it is this process that renders mitochondria …

Mammalian adrenodoxin (ferredoxin 1; Fdx1) is essential for the synthesis of various steroid
hormones in adrenal glands. As a member of the [2Fe-2S] cluster-containing ferredoxin …

Loss of p53 gene function, which occurs in most colon cancer cells, has been shown to
abolish the apoptotic response to 5-fluorouracil (5-FU). To identify genes downstream of p53 …

One of the essential roles of the human placenta is to produce the steroid hormone
progesterone, which is required for the maintenance of pregnancy. The rate-determining …

Abstract Iron-sulfur (Fe/S) clusters require a complex set of proteins to become assembled
and incorporated into apoproteins in a living cell. Researchers have described three distinct …

The mitochondrial proteins Isu1p and Isu2p play an essential role in the maturation of
cellular iron–sulfur (Fe/S) proteins in eukaryotes. By radiolabelling of yeast cells with 55 Fe …