Background Many metabolites serve as important signalling molecules to adjust cellular
activities and functions based on nutrient availability. Links between acetyl-CoA metabolism …

Protein post-translational modifications play key roles in multiple cellular processes by
allowing rapid reprogramming of individual protein functions. Acylation, one of the most …

Post-translational modifications (PTMs) provide a rapid response to stimuli, finely tuning
metabolism and gene expression and maintain homeostasis. Advances in mass …

Background and Purpose Gut microbiota dysbiosis induced by acute pancreatitis (AP)
exacerbates pancreatic injury and systemic inflammatory responses. The alleviation of gut …

Post-translational modifications (PTMs) alter protein structure, function, and localization and
play a pivotal role in physiological and pathophysiological conditions. Many PTMs arise from …

Significance: Nicotinamide adenine dinucleotide (NAD+) spans diverse roles in biology,
serving as both an important redox cofactor in metabolism and a substrate for signaling …

Succinylation is a post-translational modification of protein lysine residues with succinyl
groups derived from succinyl CoA. Succinylation is considered a significant post …

In the US, alcohol-associated liver disease (ALD) impacts millions of people and is a major
healthcare burden. While the pathology of ALD is unmistakable, the molecular mechanisms …

Melatonin (MT) has often been used to support good sleep quality, especially during the
COVID-19 pandemic, as many have suffered from stress-related disrupted sleep patterns. It …

This review provides an update on recent findings from basic, translational, and clinical
studies on the molecular mechanisms of mitochondrial dysfunction and apoptosis of …