Notch signaling induced by canonical Notch ligands is critical for normal embryonic
development and tissue homeostasis through the regulation of a variety of cell fate decisions …

Notch is an evolutionarily conserved local cell signaling mechanism that participates in a
variety of cellular processes: cell fate specification, differentiation, proliferation, apoptosis …

Hundreds of E3 ligases play a critical role in recognizing specific substrates for modification
by ubiquitin (Ub). Separating genuine targets of E3s from E3-interactors remains a …

Left ventricular noncompaction (LVNC) causes prominent ventricular trabeculations and
reduces cardiac systolic function. The clinical presentation of LVNC ranges from …

The Notch signaling pathway regulates a diverse array of cell types and cellular processes
and is tightly regulated by ligand binding. Both canonical and noncanonical Notch ligands …

Notch signaling is an ancient intercellular signaling mechanism that plays myriad roles
during vascular development and physiology in vertebrates. These roles include regulation …

Notch signaling is an evolutionarily conserved, intercellular signaling mechanism that plays
myriad roles during vascular development and physiology in vertebrates. These roles …

The molecular mechanisms promoting lineage-specific commitment of human mesenchymal
(skeletal or stromal) stem cells (hMSCs) into adipocytes (ADs) are not fully understood …

The Notch ligands Dll1 and Dll3 are coexpressed in the presomitic mesoderm of mouse
embryos. Despite their coexpression, mutations in Dll1 and Dll3 cause strikingly different …

Ubiquitination is a posttranslational mechanism that controls diverse cellular processes. We
focus here on the ubiquitin ligase Fbw7, a recently identified hematopoietic tumor …