Web-based multi-omics integration using the analyst software suite
The growing number of multi-omics studies demands clear conceptual workflows coupled
with easy-to-use software tools to facilitate data analysis and interpretation. This protocol …
with easy-to-use software tools to facilitate data analysis and interpretation. This protocol …
A review of deep learning applications in human genomics using next-generation sequencing data
WS Alharbi, M Rashid - Human Genomics, 2022 - Springer
Genomics is advancing towards data-driven science. Through the advent of high-throughput
data generating technologies in human genomics, we are overwhelmed with the heap of …
data generating technologies in human genomics, we are overwhelmed with the heap of …
Reaching the end-game for GWAS: machine learning approaches for the prioritization of complex disease loci
Genome-wide association studies (GWAS) have revealed thousands of genetic loci that
underpin the complex biology of many human traits. However, the strength of GWAS–the …
underpin the complex biology of many human traits. However, the strength of GWAS–the …
Morphology and gene expression profiling provide complementary information for mapping cell state
Morphological and gene expression profiling can cost-effectively capture thousands of
features in thousands of samples across perturbations by disease, mutation, or drug …
features in thousands of samples across perturbations by disease, mutation, or drug …
Ethical implications of epigenetics in the era of personalized medicine
J Santaló, M Berdasco - Clinical epigenetics, 2022 - Springer
Given the increasing research activity on epigenetics to monitor human diseases and its
connection with lifestyle and environmental expositions, the field of epigenetics has attracted …
connection with lifestyle and environmental expositions, the field of epigenetics has attracted …
DNA methylation as a mediator of genetic and environmental influences on Parkinson's disease susceptibility: Impacts of alpha-Synuclein, physical activity, and …
SL Schaffner, MS Kobor - Frontiers in genetics, 2022 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disorder with a complex etiology and
increasing prevalence worldwide. As PD is influenced by a combination of genetic and …
increasing prevalence worldwide. As PD is influenced by a combination of genetic and …
The potential of DNA methylation as a biomarker for obesity and smoking
A Heikkinen, S Bollepalli… - Journal of internal …, 2022 - Wiley Online Library
DNA methylation is an epigenetic modification that has consistently been shown to be linked
with a variety of human traits and diseases. Because DNA methylation is dynamic and …
with a variety of human traits and diseases. Because DNA methylation is dynamic and …
Epigenetics: linking early postnatal nutrition to obesity programming?
L Marousez, J Lesage, D Eberlé - Nutrients, 2019 - mdpi.com
Despite constant research and public policy efforts, the obesity epidemic continues to be a
major public health threat, and new approaches are urgently needed. It has been shown that …
major public health threat, and new approaches are urgently needed. It has been shown that …
Chile Pepper (Capsicum) Breeding and Improvement in the “Multi-Omics” Era
Chile pepper (Capsicum spp.) is a major culinary, medicinal, and economic crop in most
areas of the world. For more than hundreds of years, chile peppers have “defined” the state …
areas of the world. For more than hundreds of years, chile peppers have “defined” the state …
Histone post-translational modifications as potential therapeutic targets for pain management
JV Torres-Perez, J Irfan, MR Febrianto… - Trends in …, 2021 - cell.com
Effective pharmacological management of pain associated with tissue pathology is an unmet
medical need. Transcriptional modifications in nociceptive pathways are pivotal for the …
medical need. Transcriptional modifications in nociceptive pathways are pivotal for the …