Apolipoprotein E isoforms and lipoprotein metabolism

MC Phillips - IUBMB life, 2014 - Wiley Online Library
Apolipoprotein (apo) E is a 299‐residue protein which functions as a key regulator of plasma
lipid levels. Human apoE exists as three common isoforms and the parent form, apoE3 …

Structure and physiologic function of the low-density lipoprotein receptor

H Jeon, SC Blacklow - Annu. Rev. Biochem., 2005 - annualreviews.org
▪ Abstract The low-density lipoprotein receptor (LDLR) is responsible for uptake of
cholesterol-carrying lipoprotein particles into cells. The receptor binds lipoprotein particles at …

Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins

H Saito, S Lund-Katz, MC Phillips - Progress in lipid research, 2004 - Elsevier
Exchangeable apolipoproteins function in lipid transport as structural components of
lipoprotein particles, cofactors for enzymes and ligands for cell-surface receptors. Recent …

The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor

J Ruiz, D Kouiavskaia, M Migliorini, S Robinson… - Journal of lipid …, 2005 - ASBMB
Apolipoprotein E (apoE) associates with lipoproteins and mediates their interaction with
members of the LDL receptor family. ApoE exists as three common isoforms that have …

Hepatitis C virus attachment mediated by apolipoprotein E binding to cell surface heparan sulfate

J Jiang, W Cun, X Wu, Q Shi, H Tang, G Luo - Journal of virology, 2012 - Am Soc Microbiol
Viruses are known to use virally encoded envelope proteins for cell attachment, which is the
very first step of virus infection. In the present study, we have obtained substantial evidence …

Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors

C Fisher, N Beglova, SC Blacklow - Molecular cell, 2006 - cell.com
Proteins of the low-density lipoprotein receptor (LDLR) family are remarkable in their ability
to bind an extremely diverse range of protein and lipoprotein ligands, yet the basis for ligand …

Self-assembled porphyrin nanodiscs with structure-dependent activation for phototherapy and photodiagnostic applications

KK Ng, JF Lovell, A Vedadi, T Hajian, G Zheng - ACS nano, 2013 - ACS Publications
The abilities to deliver and subsequently activate a therapeutic at the intended site of action
are two important challenges in the synthesis of novel nanoparticles. Poor tumor …

Lingonberries reduce atherosclerosis in Apoe‐/‐ mice in association with altered gut microbiota composition and improved lipid profile

C Matziouridou, N Marungruang… - Molecular nutrition & …, 2016 - Wiley Online Library
Scope To investigate the efficacy of lingonberries in prevention of atherosclerosis, using
atherosclerosis‐prone Apoe‐/‐mice and to clarify whether effects were associated with …

Tailored theranostic apolipoprotein E3 porphyrin-lipid nanoparticles target glioblastoma

MA Rajora, L Ding, M Valic, W Jiang, M Overchuk… - Chemical …, 2017 - pubs.rsc.org
The development of curative glioblastoma treatments and tumour-specific contrast agents
that can overcome the blood–brain barrier (BBB) and infiltrative tumour morphology remains …

An apolipoprotein E-derived peptide mediates uptake of sterically stabilized liposomes into brain capillary endothelial cells

I Sauer, IR Dunay, K Weisgraber, M Bienert… - Biochemistry, 2005 - ACS Publications
A promising strategy to solve the problems of insufficient membrane penetration of drugs
and low target specificity is the localization of targeting and uptake-facilitating ligands on the …