Tramadol, a centrally acting analgesic structurally related to codeine and morphine, consists
of two enantiomers, both of which contribute to analgesic activity via different …

Tramadol is a synthetic, centrally acting analgesic agent with 2 distinct, synergistic
mechanisms of action, acting as both a weak opioid agonist and an inhibitor of monoamine …

Genetic polymorphisms result in absent enzyme activity of CYP2D6 (poor metabolizers, PM)
in about 10% of the Caucasian population. This study investigates whether the PM genotype …

The atypical opioid, tramadol, has recently been introduced into Australia and New Zealand.
Tramadol's efficacy in a wide range of acute and chronic pain states, its multi-formulation …

Objective To compare morphine with tramadol for the management of early postoperative
pain following ovariohysterectomy after pyometra in dogs. Study design Prospective …

The management of postoperative pain in elderly patients can be a difficult task. Older
patients have co-existing diseases and concurrent medications, diminished functional status …

Tramadol is a weak centrally acting analgesic and it might provide efficacious postoperative
pain relief with minimal sedative effects in the use of intravenous patient-controlled …

Background STARDOM2 is a randomized, double‐blind, phase 3 trial evaluating the efficacy
and safety of co‐crystal of tramadol‐celecoxib (CTC)—a first‐in‐class analgesic co‐crystal …

Background General anaesthesia is usually associated with unconsciousness.'Awareness'
is when patients have postoperative recall of events or experiences during …

PURPOSE: We compared the efficacy of tramadol given before or immediately after surgical
extraction of an impacted mandibular third molar under local anesthesia. MATERIALS AND …