Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …

Recent studies have provided further evidence for the presence of many components of the
RAS in glomerular structures, which supports the importance of locally produced …

Monocyte/macrophage recruitment is closely associated with the degree of hypertensive
renal injury. We investigated the direct role of macrophages using liposome-encapsulated …

Endothelin (ET) is one of the most potent renal vasoconstrictors. Endothelin plays an
essential role in the regulation of renal blood flow, glomerular filtration, sodium and water …

The regulation of extracellular fluid volume is a key component of blood pressure
homeostasis. Long‐term blood pressure is stabilized by the acute pressure natriuresis …

Uridine adenosine tetraphosphate (Up 4 A), biosynthesized by activation of vascular
endothelial growth factor receptor (VEGFR) 2, was initially identified as a potent endothelium …

High dietary salt is common in Western countries and is an important contributor to
increased cardiovascular disease. Autoregulation of renal blood flow (RBF) and glomerular …

Hypertension is the leading cause of morbidity and mortality globally among all
cardiovascular diseases. Purinergic signalling plays a crucial role in hypertension through …

Chronic angiotensin II (ANG II) infusion for 1 or 2 wk leads to progressive hypertension and
induces inward hypertrophic remodeling in preglomerular vessels, which is associated with …

Extracellular nucleotides such as adenosine-5′-triphosphate (ATP) and reactive oxygen
species are essential local signaling molecules in the kidney. However, measurements of …