Metabolomics technology and bioinformatics for precision medicine
Precision medicine is rapidly emerging as a strategy to tailor medical treatment to a small
group or even individual patients based on their genetics, environment and lifestyle …
group or even individual patients based on their genetics, environment and lifestyle …
Hyphenated MS-based targeted approaches in metabolomics
While global metabolic profiling (untargeted metabolomics) has been the center of much
interest and research activity in the past few decades, more recently targeted metabolomics …
interest and research activity in the past few decades, more recently targeted metabolomics …
High throughput and quantitative measurement of microbial metabolome by gas chromatography/mass spectrometry using automated alkyl chloroformate …
The ability to identify and quantify small molecule metabolites derived from gut microbial–
mammalian cometabolism is essential for the understanding of the distinct metabolic …
mammalian cometabolism is essential for the understanding of the distinct metabolic …
Strategies and challenges in method development and validation for the absolute quantification of endogenous biomarker metabolites using liquid chromatography …
Metabolomics is a dynamically evolving field, with a major application in identifying
biomarkers for drug development and personalized medicine. Numerous metabolomic …
biomarkers for drug development and personalized medicine. Numerous metabolomic …
Sample preparation optimization in fecal metabolic profiling
Metabolomic analysis of feces can provide useful insight on the metabolic status, the
health/disease state of the human/animal and the symbiosis with the gut microbiome. As a …
health/disease state of the human/animal and the symbiosis with the gut microbiome. As a …
A reliable LC-MS/MS method for the quantification of natural amino acids in mouse plasma: method validation and application to a study on amino acid dynamics …
A simple and fast LC-MS/MS method was developed and validated for simultaneous
quantification of 20 proteinogenic l-amino acids (AAs) in a small volume (5 μL) of mouse …
quantification of 20 proteinogenic l-amino acids (AAs) in a small volume (5 μL) of mouse …
Metaproteomic and metabolomic approaches for characterizing the gut microbiome
The gut microbiome has been shown to play a significant role in human healthy and
diseased states. The dynamic signaling that occurs between the host and microbiome is …
diseased states. The dynamic signaling that occurs between the host and microbiome is …
[HTML][HTML] High performance liquid chromatography–tandem mass spectrometry quantification of tryptophan metabolites in human serum and stool–Application to …
A Desmons, L Humbert, T Eguether, P Krasniqi… - … of Chromatography A, 2022 - Elsevier
Tryptophan, an essential amino acid, and its metabolites are involved in many physiological
processes including neuronal functions, immune system, and gut homeostasis. Alterations to …
processes including neuronal functions, immune system, and gut homeostasis. Alterations to …
Analysis of urinary organic acids by gas chromatography tandem mass spectrometry method for metabolic profiling applications
T Mouskeftara, C Virgiliou, G Theodoridis… - … of Chromatography A, 2021 - Elsevier
A sensitive, accurate and precise method was developed for the quantification of a large
number of organic acids in human urine by GC-MS/MS. The analytes were selected based …
number of organic acids in human urine by GC-MS/MS. The analytes were selected based …
An untargeted and pseudotargeted metabolomic combination approach to identify differential markers to distinguish live from dead pork meat by liquid …
M Cao, J Zhang, R Zhang, J Wang, W Gu… - … of Chromatography A, 2020 - Elsevier
An untargeted and pseudotargeted metabolomic combination approach was developed to
identify reliable and stable differential markers which can distinguish between pork meat …
identify reliable and stable differential markers which can distinguish between pork meat …