Catalytic approaches to multicomponent reactions: A critical review and perspectives on the roles of catalysis

BAD Neto, RO Rocha, MO Rodrigues - Molecules, 2021 - mdpi.com
In this review, we comprehensively describe catalyzed multicomponent reactions (MCRs)
and the multiple roles of catalysis combined with key parameters to perform these …

Green synthesis of biologically active heterocycles of medicinal importance: A review

R Nishanth Rao, S Jena, M Mukherjee, B Maiti… - Environmental …, 2021 - Springer
Heterocyclic moieties are basic skeletons for 80% of commercial medicines according to the
US retail market in 2014–2015, yet many actual synthetic methods are not sustainable …

Multicomponent reactions: advanced tools for sustainable organic synthesis

RC Cioc, E Ruijter, RVA Orru - Green Chemistry, 2014 - pubs.rsc.org
Sustainable or green chemistry has established firm ground providing essential design
criteria for the development of efficient chemical syntheses of complex, high added value …

The Groebke‐Blackburn‐Bienaymé Reaction

A Boltjes, A Dömling - European Journal of Organic Chemistry, 2019 - Wiley Online Library
Imidazo [1, 2‐a] pyridine is a well‐known scaffold in many marketed drugs, such as
Zolpidem, Minodronic acid, Miroprofen and DS‐1 and it also serves as a broadly applied …

Diversity-oriented synthesis of fused-imidazole derivatives via Groebke–Blackburn–Bienayme reaction: a review

N Devi, RK Rawal, V Singh - Tetrahedron, 2015 - Elsevier
In recent time, diversity-oriented synthesis of small chemical entities has been emerged as a
possible tool for exploring the intersections between chemistry and biology. These small …

2-Aminopyridine–an unsung hero in drug discovery

RN Rao, K Chanda - Chemical Communications, 2022 - pubs.rsc.org
2-Aminopyridine is a simple, low molecular weight and perfectly functionalised moiety
known for the synthesis of diverse biological molecules. Many pharmaceutical companies …

Microwave-assisted multicomponent reactions in heterocyclic chemistry and mechanistic aspects

S Gulati, SE John… - Beilstein Journal of Organic …, 2021 - beilstein-journals.org
Microwave-assisted (MWA) multicomponent reactions (MCRs) have successfully emerged
as one of the useful tools in the synthesis of biologically relevant heterocycles. These …

One-Pot Regiospecific Synthesis of Imidazo[1,2-a]pyridines: A Novel, Metal-Free, Three-Component Reaction for the Formation of C–N, C–O, and C–S Bonds

H Cao, X Liu, L Zhao, J Cen, J Lin, Q Zhu, M Fu - Organic letters, 2014 - ACS Publications
One-Pot Regiospecific Synthesis of Imidazo[1,2-a]pyridines: A Novel, Metal-Free, Three-Component
Reaction for the Formation of C–N, C–O, and C–S Bonds | Organic Letters ACS ACS …

Recent advances on the transition-metal-catalyzed synthesis of imidazopyridines: an updated coverage

GK Reen, A Kumar, P Sharma - Beilstein Journal of Organic …, 2019 - beilstein-journals.org
A comprehensive account of recent advances in the synthesis of imidazopyridines, assisted
through transition-metal-catalyzed multicomponent reactions, C–H activation …

Functionalized benzimidazole scaffolds: privileged heterocycle for drug design in therapeutic medicine

OO Ajani, DV Aderohunmu, CO Ikpo… - Archiv der …, 2016 - Wiley Online Library
Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of
biologically active compounds which are therapeutically useful agents in drug discovery and …