Abstract The Mycobacterium tuberculosis (Mtb) DosRST two-component regulatory system
promotes the survival of Mtb during non-replicating persistence (NRP). NRP bacteria help …

Recent technological advances has led to the generation, storage, and sharing of colossal
sets of information ('big data'), and the expansion of 'omics' in science. To date, genomics …

Mycobacterium tuberculosis (Mtb) possesses a two-component regulatory system, DosRST,
that enables Mtb to sense host immune cues and establish a state of nonreplicating …

Lanthanide (Ln) elements are utilized as cofactors for catalysis by XoxF-type methanol
dehydrogenases (MDHs). A primary assumption is that XoxF enzymes produce formate from …

Colorectal cancer (CRC) ranks the third most common cancer type in both men and women.
Besides the known genetic and epigenetic changes in the gut epithelial cells, we now know …

Successful host colonization by bacteria requires sensing and response to the local ionic
milieu, and coordination of responses with the maintenance of ionic homeostasis in the face …

The ability of Mycobacterium tuberculosis (Mtb) to adapt to its surrounding environment is
critical for the bacterium to successfully colonize its host. Transcriptional changes are a vital …

Mycobacterium tuberculosis (Mtb) must sense and adapt to immune pressures such as
acidic pH during pathogenesis. The goal of this study was to isolate compounds that inhibit …

ESX (ESAT-6 system) export systems play diverse roles across mycobacterial species.
Interestingly, genetic disruption of ESX systems in different species does not result in an …

Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, is a deadly
disease that requires a long course of treatment. The emergence of drug-resistant strains …