The rise in antimicrobial resistant bacteria threatens the current methods utilized to treat
bacterial infections. The development of novel therapeutic agents is crucial in avoiding a …

This review examines the role of reactive species RS (of oxygen ROS, nitrogen RNS and
halogen RHS) on innate immunity. The importance of these species in innate immunity was …

Myeloid cells infiltrating tumors are gaining ever growing attention in the last years because
their pro-tumor and immunosuppressive functions are relevant for disease progression and …

The mechanisms for maintaining oral cavity homeostasis are subject to the constant
influence of many environmental factors, including various chemicals and microorganisms …

Nowadays, cancer has become the second highest leading cause of death, and it is
expected to continue to affect the population in forthcoming years. Additionally, treatment …

The rise in antimicrobial resistant bacteria is limiting the number of effective treatments for
bacterial infections. Escherichia coli and Pseudomonas aeruginosa are two of the …

COVID-19 is characterized by hyperactivation by inflammatory cytokines and recruitment of
macrophages, neutrophils, and other immune cells, all hallmarks of a strong inflammatory …

Members of oral bacterial communities form biofilms not only on tooth surfaces but also on
the surface of dental implants that replace natural teeth. Prolonged interaction of host cells …

2'3'-cGAMP is a key molecule in the cGAS-STING pathway. This cyclic dinucleotide is
produced by the cytosolic DNA sensor cGAS in response to the presence of aberrant dsDNA …

Host defense peptides (HDPs) are naturally occurring polypeptide sequences that, in
addition to being active against bacteria, fungi, viruses, and other parasites, may stimulate …