The potential of human peptide LL-37 as an antimicrobial and anti-biofilm agent
KE Ridyard, J Overhage - Antibiotics, 2021 - mdpi.com
The rise in antimicrobial resistant bacteria threatens the current methods utilized to treat
bacterial infections. The development of novel therapeutic agents is crucial in avoiding a …
bacterial infections. The development of novel therapeutic agents is crucial in avoiding a …
The role of reactive species on innate immunity
CMC Andrés, JM Pérez de la Lastra, CA Juan, FJ Plou… - Vaccines, 2022 - mdpi.com
This review examines the role of reactive species RS (of oxygen ROS, nitrogen RNS and
halogen RHS) on innate immunity. The importance of these species in innate immunity was …
halogen RHS) on innate immunity. The importance of these species in innate immunity was …
Macrophages and cancer stem cells: a malevolent alliance
P Allavena, E Digifico, C Belgiovine - Molecular Medicine, 2021 - Springer
Myeloid cells infiltrating tumors are gaining ever growing attention in the last years because
their pro-tumor and immunosuppressive functions are relevant for disease progression and …
their pro-tumor and immunosuppressive functions are relevant for disease progression and …
Cathelicidin LL-37 in health and diseases of the oral cavity
J Tokajuk, P Deptuła, E Piktel, T Daniluk… - Biomedicines, 2022 - mdpi.com
The mechanisms for maintaining oral cavity homeostasis are subject to the constant
influence of many environmental factors, including various chemicals and microorganisms …
influence of many environmental factors, including various chemicals and microorganisms …
Natural peptides inducing cancer cell death: Mechanisms and properties of specific candidates for cancer therapeutics
PA Trinidad-Calderón, CD Varela-Chinchilla… - Molecules, 2021 - mdpi.com
Nowadays, cancer has become the second highest leading cause of death, and it is
expected to continue to affect the population in forthcoming years. Additionally, treatment …
expected to continue to affect the population in forthcoming years. Additionally, treatment …
Synergy between Human Peptide LL-37 and Polymyxin B against Planktonic and Biofilm Cells of Escherichia coli and Pseudomonas aeruginosa
KE Ridyard, M Elsawy, D Mattrasingh, D Klein… - Antibiotics, 2023 - mdpi.com
The rise in antimicrobial resistant bacteria is limiting the number of effective treatments for
bacterial infections. Escherichia coli and Pseudomonas aeruginosa are two of the …
bacterial infections. Escherichia coli and Pseudomonas aeruginosa are two of the …
Upregulating human cathelicidin antimicrobial peptide LL-37 expression may prevent severe COVID-19 inflammatory responses and reduce microthrombosis
KM Aloul, JE Nielsen, EB Defensor, JS Lin… - Frontiers in …, 2022 - frontiersin.org
COVID-19 is characterized by hyperactivation by inflammatory cytokines and recruitment of
macrophages, neutrophils, and other immune cells, all hallmarks of a strong inflammatory …
macrophages, neutrophils, and other immune cells, all hallmarks of a strong inflammatory …
[HTML][HTML] Bioactive coatings for dental implants: A review of alternative strategies to prevent peri-implantitis induced by anaerobic bacteria
G Körtvélyessy, T Tarjányi, ZL Baráth, J Minarovits… - Anaerobe, 2021 - Elsevier
Members of oral bacterial communities form biofilms not only on tooth surfaces but also on
the surface of dental implants that replace natural teeth. Prolonged interaction of host cells …
the surface of dental implants that replace natural teeth. Prolonged interaction of host cells …
cGAMP the travelling messenger
HTW Blest, L Chauveau - Frontiers in Immunology, 2023 - frontiersin.org
2'3'-cGAMP is a key molecule in the cGAS-STING pathway. This cyclic dinucleotide is
produced by the cytosolic DNA sensor cGAS in response to the presence of aberrant dsDNA …
produced by the cytosolic DNA sensor cGAS in response to the presence of aberrant dsDNA …
The LL-37 domain: A clue to cathelicidin immunomodulatory response?
ML Leite, HM Duque, GR Rodrigues, NB da Cunha… - Peptides, 2023 - Elsevier
Host defense peptides (HDPs) are naturally occurring polypeptide sequences that, in
addition to being active against bacteria, fungi, viruses, and other parasites, may stimulate …
addition to being active against bacteria, fungi, viruses, and other parasites, may stimulate …