Chronic Myeloid Leukemia (CML) is a clonal disease characterized by the presence of the
Philadelphia (Ph+) chromosome and its oncogenic product, BCR-ABL, a constitutively active …

Tyrosine kinases (TKs) are involved in key signaling events/pathways that regulate cancer
cell proliferation, apoptosis, angiogenesis and metastasis. Deregulated activity of TKs has …

Targeted therapy in the form of selective tyrosine kinase inhibitors (TKI) has transformed the
approach to management of chronic myeloid leukemia (CML) and dramatically improved …

Tyrosine kinases (TKs) play an important role in pathways that regulate cancer cell
proliferation, apoptosis, angiogenesis and metastasis. Aberrant activity of TKs has been …

The aim of this study was to investigate the gene and protein expression profiles of important
drug-transporting proteins in human cell lines commonly used for studies of drug transport …

Background Several signal transduction pathways have been reported being involved in the
acquisition of P-glycoprotein (P-gp) mediated multi-drug resistance (MDR) upon exposure to …

Overexpression of renin angiotensin system (RAS) components and nuclear factor-kappa B
(NF-kB) has a key role in various cancers. Blockade of RAS and NF-kB pathway has been …

Colorectal cancer is the third most common malignancy in the United States. Modest
advances with therapeutic approaches that include oxaliplatin (l-OHP) have brought the …

The development of imatinib resistance has become a significant therapeutic problem in
which the etiology seems to be multifactorial and poorly understood. As of today, clinical …

Lung cancer is the most commonly diagnosed cancer in the world.“Driver” and “passenger”
mutations identified in lung cancer indicate that genetics play a major role in the …