Intestinal in vitro and ex vivo Models to Study Host-Microbiome Interactions and Acute Stressors

SC Pearce, HG Coia, JP Karl… - Frontiers in …, 2018 - frontiersin.org
The gut microbiome is extremely important for maintaining homeostasis with host intestinal
epithelial, neuronal, and immune cells and this host-microbe interaction is critical during …

The porcine innate immune system: an update

KH Mair, C Sedlak, T Käser, A Pasternak… - Developmental & …, 2014 - Elsevier
Over the last few years, we have seen an increasing interest and demand for pigs in
biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans …

Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway

H Yan, KM Ajuwon - PloS one, 2017 - journals.plos.org
The intestinal epithelial barrier, composed of epithelial cells, tight junction proteins and
intestinal secretions, prevents passage of luminal substances and antigens through the …

Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production

R Kang, R Li, P Dai, Z Li, Y Li, C Li - Environmental pollution, 2019 - Elsevier
Deoxynivalenol (DON) frequently detected in a wide range of foods and feeds, inducing
cytotoxicity to animals and humans. To investigate the underlying mechanism of DON …

Porcine milk-derived exosomes promote proliferation of intestinal epithelial cells

T Chen, MY Xie, JJ Sun, RS Ye, X Cheng, RP Sun… - Scientific reports, 2016 - nature.com
Milk-derived exosomes were identified as a novel mechanism of mother-to-child
transmission of regulatory molecules, but their functions in intestinal tissues of neonates are …

Hippophae rhamnoides polysaccharides protect IPEC-J2 cells from LPS-induced inflammation, apoptosis and barrier dysfunction in vitro via inhibiting TLR4/NF-κB …

L Zhao, M Li, K Sun, S Su, T Geng, H Sun - International Journal of …, 2020 - Elsevier
Inflammatory response caused by early weaning stress in piglets is associated with various
diseases. The Hippophae rhamnoides polysaccharide (HRP) exhibits anti-inflammatory …

Thymol improves barrier function and attenuates inflammatory responses in porcine intestinal epithelial cells during lipopolysaccharide (LPS)-induced inflammation

FA Omonijo, S Liu, Q Hui, H Zhang… - Journal of agricultural …, 2018 - ACS Publications
It is well-known that essential oil thymol exhibits antibacterial activity. The protective effects
of thymol on pig intestine during inflammation is yet to be investigated. In this study, an in …

Porcine IPEC-J2 intestinal epithelial cells in microbiological investigations

AJ Brosnahan, DR Brown - Veterinary microbiology, 2012 - Elsevier
IPEC-J2 cells are porcine intestinal columnar epithelial cells that were isolated from
neonatal piglet mid-jejunum. This cell line forms polarized monolayers with high …

L-arginine inhibited inflammatory response and oxidative stress induced by lipopolysaccharide via arginase-1 signaling in IPEC-J2 cells

Y Qiu, X Yang, L Wang, K Gao, Z Jiang - International journal of molecular …, 2019 - mdpi.com
This study aimed to explore the effect of L-arginine on lipopolysaccharide (LPS)-induced
inflammatory response and oxidative stress in IPEC-2 cells. We found that the expression of …

Chitosan oligosaccharide-mediated attenuation of LPS-induced inflammation in IPEC-J2 cells is related to the TLR4/NF-κB signaling pathway

L Shi, B Fang, Y Yong, X Li, D Gong, J Li, T Yu… - Carbohydrate …, 2019 - Elsevier
The protective mechanism of chitosan oligosaccharide (COS) against lipopolysaccharides
(LPS)-induced inflammatory responses in IPEC-J2 and in mice with DSS dextran sulfate …