Intestinal in vitro and ex vivo Models to Study Host-Microbiome Interactions and Acute Stressors
The gut microbiome is extremely important for maintaining homeostasis with host intestinal
epithelial, neuronal, and immune cells and this host-microbe interaction is critical during …
epithelial, neuronal, and immune cells and this host-microbe interaction is critical during …
The porcine innate immune system: an update
KH Mair, C Sedlak, T Käser, A Pasternak… - Developmental & …, 2014 - Elsevier
Over the last few years, we have seen an increasing interest and demand for pigs in
biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans …
biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans …
Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway
The intestinal epithelial barrier, composed of epithelial cells, tight junction proteins and
intestinal secretions, prevents passage of luminal substances and antigens through the …
intestinal secretions, prevents passage of luminal substances and antigens through the …
Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production
R Kang, R Li, P Dai, Z Li, Y Li, C Li - Environmental pollution, 2019 - Elsevier
Deoxynivalenol (DON) frequently detected in a wide range of foods and feeds, inducing
cytotoxicity to animals and humans. To investigate the underlying mechanism of DON …
cytotoxicity to animals and humans. To investigate the underlying mechanism of DON …
Porcine milk-derived exosomes promote proliferation of intestinal epithelial cells
Milk-derived exosomes were identified as a novel mechanism of mother-to-child
transmission of regulatory molecules, but their functions in intestinal tissues of neonates are …
transmission of regulatory molecules, but their functions in intestinal tissues of neonates are …
Hippophae rhamnoides polysaccharides protect IPEC-J2 cells from LPS-induced inflammation, apoptosis and barrier dysfunction in vitro via inhibiting TLR4/NF-κB …
L Zhao, M Li, K Sun, S Su, T Geng, H Sun - International Journal of …, 2020 - Elsevier
Inflammatory response caused by early weaning stress in piglets is associated with various
diseases. The Hippophae rhamnoides polysaccharide (HRP) exhibits anti-inflammatory …
diseases. The Hippophae rhamnoides polysaccharide (HRP) exhibits anti-inflammatory …
Thymol improves barrier function and attenuates inflammatory responses in porcine intestinal epithelial cells during lipopolysaccharide (LPS)-induced inflammation
It is well-known that essential oil thymol exhibits antibacterial activity. The protective effects
of thymol on pig intestine during inflammation is yet to be investigated. In this study, an in …
of thymol on pig intestine during inflammation is yet to be investigated. In this study, an in …
Porcine IPEC-J2 intestinal epithelial cells in microbiological investigations
AJ Brosnahan, DR Brown - Veterinary microbiology, 2012 - Elsevier
IPEC-J2 cells are porcine intestinal columnar epithelial cells that were isolated from
neonatal piglet mid-jejunum. This cell line forms polarized monolayers with high …
neonatal piglet mid-jejunum. This cell line forms polarized monolayers with high …
L-arginine inhibited inflammatory response and oxidative stress induced by lipopolysaccharide via arginase-1 signaling in IPEC-J2 cells
Y Qiu, X Yang, L Wang, K Gao, Z Jiang - International journal of molecular …, 2019 - mdpi.com
This study aimed to explore the effect of L-arginine on lipopolysaccharide (LPS)-induced
inflammatory response and oxidative stress in IPEC-2 cells. We found that the expression of …
inflammatory response and oxidative stress in IPEC-2 cells. We found that the expression of …
Chitosan oligosaccharide-mediated attenuation of LPS-induced inflammation in IPEC-J2 cells is related to the TLR4/NF-κB signaling pathway
L Shi, B Fang, Y Yong, X Li, D Gong, J Li, T Yu… - Carbohydrate …, 2019 - Elsevier
The protective mechanism of chitosan oligosaccharide (COS) against lipopolysaccharides
(LPS)-induced inflammatory responses in IPEC-J2 and in mice with DSS dextran sulfate …
(LPS)-induced inflammatory responses in IPEC-J2 and in mice with DSS dextran sulfate …