Mitochondrial-derived vesicles in metabolism, disease, and aging

T König, HM McBride - Cell Metabolism, 2024 - cell.com
Mitochondria are central hubs of cellular metabolism and are tightly connected to signaling
pathways. The dynamic plasticity of mitochondria to fuse, divide, and contact other …

Mitochondrial Extracellular Vesicles: A Promising Avenue for Diagnosing and Treating Lung Diseases

F Ding, M Zhou, Y Ren, Y Li, J Xiang, Y Li, J Yu… - ACS …, 2024 - ACS Publications
Mitochondria, pivotal organelles governing cellular biosynthesis, energy metabolism, and
signal transduction, maintain dynamic equilibrium through processes such as biogenesis …

Tollip deficiency exaggerates airway type 2 inflammation in mice exposed to allergen and influenza A virus: role of the ATP/IL-33 signaling axis

HR Nouri, N Schaunaman, M Kraft, L Li… - Frontiers in …, 2023 - frontiersin.org
Toll-interacting protein (Tollip) is a negative regulator of the pro-inflammatory response to
viruses, including influenza A virus (IAV). Genetic variation of Tollip has been associated …

Biogenesis of extracellular vesicles from the pathogen perspective: Transkingdom strategies for delivering messages

A Rojas, N Regev-Rudzki - Current Opinion in Cell Biology, 2024 - Elsevier
EVs are nanoparticles enclosing proteins, nucleic acids and lipids released by cells and are
essential for their metabolism and useful for intercellular communication. The importance of …

Mitochondrial derived vesicles‐Quo Vadis?

R Hazan, O Pines, A Saada - The FEBS Journal, 2024 - Wiley Online Library
Mitochondria are dynamic, intracellular organelles with a separate genome originating from
prokaryotes. They perform numerous functions essential for cellular metabolism and energy …

Mitochondrial derived vesicle-carrying protein MIGA2 promotes copper-induced autophagosomes-lysosomes fusion by regulating ATG14

Q Li, P Guo, S Wang, Y Feng, H Zhang, W Yu… - Journal of Hazardous …, 2024 - Elsevier
As an environmental pollution metal, copper (Cu) exposure-induced toxicity is closely
related to mitochondrial damage. Mitochondrial-derived vesicles (MDVs) plays an essential …

Mitochondria break free: Mitochondria-derived vesicles in aging and associated conditions

L Ferrucci, F Guerra, C Bucci, E Marzetti… - Ageing Research Reviews, 2024 - Elsevier
Mitophagy is the intracellular recycling system that disposes damaged/inefficient
mitochondria and allows biogenesis of new organelles to ensure mitochondrial quality is …

Extracellular vesicles as carriers for mitochondria: Biological functions and clinical applications

Z Liao, B Tong, W Ke, C Yang, X Wu, M Lei - Mitochondrion, 2024 - Elsevier
In recent years, research has increasingly focused on the biogenesis of extracellular
vesicles (EVs) and the sorting mechanisms for their contents. Mitochondria can be …

Mitostasis in age-associated neurodegeneration

M Panda, M Markaki, N Tavernarakis - Biochimica et Biophysica Acta (BBA) …, 2024 - Elsevier
Mitochondria are essential organelles that play crucial roles in various metabolic and
signalling pathways. Proper neuronal function is highly dependent on the health of these …

Privileged proteins with a second residence: dual targeting and conditional re‐routing of mitochondrial proteins

O Pines, M Horwitz, JM Herrmann - The FEBS Journal, 2024 - Wiley Online Library
Almost all mitochondrial proteins are encoded by nuclear genes and synthesized in the
cytosol as precursor proteins. Signals in the amino acid sequence of these precursors …