Synthetic lethal connectivity and graph transformer improve synthetic lethality prediction
Synthetic lethality (SL) has shown great promise for the discovery of novel targets in cancer.
CRISPR double-knockout (CDKO) technologies can only screen several hundred genes …
CRISPR double-knockout (CDKO) technologies can only screen several hundred genes …
Replication of pipelines determining synthetic lethal relationships and using them in predicting drug response based on the tumour transcriptome
A Carceller Pardina - 2024 - upcommons.upc.edu
Precision oncology is increasingly becoming more accessible, with multiple models
available, although they are often not reproducible. This thesis explores the application of …
available, although they are often not reproducible. This thesis explores the application of …
Multi-Layer Encoder Prediction of Gene Combination Effect (MLE-GeneCombo) Using CRISPR-Cas9 Double Knockout Data
The effect of genes in combination on cell viability can be assessed directly by evaluating
the effect of gene knockout or indirectly by evaluating synthetic lethal relationships between …
the effect of gene knockout or indirectly by evaluating synthetic lethal relationships between …