Acute lung injury (ALI) is a heterogeneous inflammatory condition associated with high
morbidity and mortality. Neutrophils play a key role in the development of different forms of …

Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon,
inevitable in kidney transplantation and one of the most important mechanisms for non-or …

Objectives: To provide an appraisal of the evolving paradigms in the pathophysiology of
sepsis and propose the evolution of a new phenotype of critically ill patients, its potential …

The presence of ROS is a constant feature in living cells metabolizing O2. ROS
concentration and compartmentation determine their physiological or pathological effects …

Dysregulated host immune responses to infection often occur, leading to sepsis, multiple
organ failure, and death. Some patients rapidly recover from sepsis, but many develop …

Severe sepsis represents a common, expensive, and deadly health care issue with limited
therapeutic options. Gaining insights into the inflammatory dysregulation that causes sepsis …

Multiple organ failure (MOF) has plagued surgical intensive care units (ICUs) for more than
four decades, and its epidemiology has evolved because advances in care have allowed …

Implementation of protocolized surveillance, diagnosis, and management of septic patients,
and of surgical sepsis patients in particular, is shown to result in significantly increased …

Acute kidney injury (AKI) remains a major problem in critically unwell children and young
adults. Ischaemia reperfusion (IR) injury is a major contributor to the development of AKI in a …

Aneurysmal subarachnoid hemorrhage (aSAH) represents only a small portion of all strokes,
but accounts for almost half of the deaths caused by stroke worldwide. Neurosurgical …