Extracellular proton concentration is at 40 nM when pH is 7.4. In disease conditions such as
brain ischemia, proton concentration can reach µM range. To respond to this increase in …

Acid-sensing ion channels (ASICs) are mainly proton-gated cation channels that are
activated by pH drops and nonproton ligands. They are part of the degenerin/epithelial …

Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels
largely expressed in the nervous system of rodents and humans. At least six isoforms …

Acid-sensing ion channels (ASICs) are proton-gated, voltage-independent sodium channels
widely expressed throughout the central and peripheral nervous systems. They are involved …

Proton-gated channels of the ASIC family are widely distributed in central neurons,
suggesting their role in common neurophysiological functions. They are involved in …

Background Dietary acid load seems to be associated with psychological disorders through
several mechanisms, and may barricade their treatment and recovery. The aim of current …

Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel
(ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout …

The transport of bicarbonate across the enterocyte cell membrane regulates the intracellular
as well as the luminal pH and is an essential part of directional fluid movement in the gut …

The transient elevation of blood glucose produced following acute ischaemic stroke (AIS)
has been described as stress-induced hyperglycaemia (SIH). SIH is common even in …

Spreading depolarization (SD) is an electrochemical wave of neuronal depolarization
mediated by extracellular K+ and glutamate, interacting with voltage‐gated and ligand …