Nanoemulsion strategy for olmesartan medoxomil improves oral absorption and extended antihypertensive activity in hypertensive rats
B Gorain, H Choudhury, A Kundu, L Sarkar… - Colloids and Surfaces B …, 2014 - Elsevier
Olmesartan medoxomil (OM) is hydrolyzed to its active metabolite olmesartan by the action
of aryl esterase to exert its antihypertensive actions by selectively blocking angiotensin II–AT …
of aryl esterase to exert its antihypertensive actions by selectively blocking angiotensin II–AT …
Ajuga bracteosa Exerts Antihypertensive Activity in l-NAME-Induced Hypertension Possibly through Modulation of Oxidative Stress, Proinflammatory Cytokines, and …
B Shaukat, MH Mehmood, B Murtaza, F Javaid… - ACS …, 2022 - ACS Publications
Ajuga bracteosa has been used in traditional medicine to treat hypertension and other
ailments. The present study has been designed to investigate the beneficial effects of A …
ailments. The present study has been designed to investigate the beneficial effects of A …
Application of physiologically based pharmacokinetic modeling in preclinical studies: A feasible strategy to practice the principles of 3Rs
Pharmacokinetic characterization plays a vital role in drug discovery and development.
Although involving numerous laboratory animals with error-prone, labor-intensive, and time …
Although involving numerous laboratory animals with error-prone, labor-intensive, and time …
Ziziphus Oxyphylla hydro-methanolic extract ameliorates hypertension in L-NAME induced hypertensive rats through NO/cGMP pathway and suppression of oxidative …
Abstract Ethnopharmacological relevance Ziziphus Oxyphylla belongs to family Ziziphus
and has been used traditionally in hypertension. It is enriched with quercetin and kaempferol …
and has been used traditionally in hypertension. It is enriched with quercetin and kaempferol …
Design and development of a self-microemulsifying drug delivery system of olmesartan medoxomil for enhanced bioavailability
Olmesartan medoxomil (OM) is a hydrophobic antihypertensive drug with low bioavailability
(26%) and is known to have adverse effects such as celiac disease and enteropathy. The …
(26%) and is known to have adverse effects such as celiac disease and enteropathy. The …
Vicinal diaryl pyrazole with tetrazole/urea scaffolds as selective angiotensin converting enzyme‐1/cyclooxygenase‐2 inhibitors: Design, synthesis, anti‐hypertensive …
As a hybrid weapon, two novel series of pyrazoles, 16a‐f and 17a‐f, targeting both COX‐2
and ACE‐1‐N‐domain, were created and their anti‐inflammatory, anti‐hypertensive, and …
and ACE‐1‐N‐domain, were created and their anti‐inflammatory, anti‐hypertensive, and …
[PDF][PDF] An evaluation of antioxidant potential of flavonoid eriodictyol in isoproterenol-induced myocardial infarction in rats
P Hariharan, M Palani, M Vaiyapuri - Indian Journal of …, 2017 - researchgate.net
Aim: The study was designed to evaluate the antioxidant potential of eriodictyol on lipid
peroxidation caused due to isoproterenol induced myocardial infarction in albino male …
peroxidation caused due to isoproterenol induced myocardial infarction in albino male …
Effect of IS01957, a para‐coumaric acid derivative on pharmacokinetic modulation of diclofenac through oral route for augmented efficacy
Diclofenac is one of the world's largest selling nonsteroidal anti‐inflammatory drugs. The
major concerns related to oral diclofenac therapy are gastrointestinal and cardiovascular …
major concerns related to oral diclofenac therapy are gastrointestinal and cardiovascular …
Molecular inhibition of prostaglandin E2 with GW627368X: Therapeutic potential and preclinical safety assessment in mouse sarcoma model
Prostaglandin E2, the major COX-2 product, acts via 4 functionally distinct prostanoid
receptors, EP (1–4). PGE-2, through its receptors, feeds back to positively increase COX-2 …
receptors, EP (1–4). PGE-2, through its receptors, feeds back to positively increase COX-2 …
Telmisartan self-nanoemulsifying drug delivery system, compared with standard telmisartan, more effectively improves hepatic fibrosis in rats
Background: This study was designed to examine effects of telmisartan; an angiotensin
receptor blocker; self-nanoemulsifying drug delivery system (SNEDDS) in reversing already …
receptor blocker; self-nanoemulsifying drug delivery system (SNEDDS) in reversing already …