Despite being collectively among the most frequent congenital developmental conditions
worldwide, differences of sex development (DSD) lack recognition and research funding. As …

Androgens play an important role in metabolic homeostasis and reproductive health in both
men and women. Androgen signalling is dependent on androgen receptor activation, mostly …

Controversy concerning the most appropriate treatment guidelines for intersex children
currently exists. This is due to a lack of long-term information regarding medical, surgical …

Steroid biosynthesis and metabolism are reflected by the serum steroid metabolome and, in
even more detail, by the 24-hour urine steroid metabolome, which can provide unique …

Computational methods are well-established tools in the drug discovery process and can be
employed for a variety of tasks. Common applications include lead identification and scaffold …

Steroid hormones regulate essential physiological processes and inadequate levels are
associated with various pathological conditions. Consequently, the process of steroid …

Androgen insensitivity syndrome encompasses a wide range of phenotypes, which are
caused by numerous different mutations in the AR gene. Detailed information on the …

Background: In this epidemiological study, we sought to capture the incidence of ambiguous
genitalia in neonates and to describe initial management strategies. Methods: We used the …

Most attempts to identify biological underpinnings of gender identity and sexual orientation
in humans have investigated effects of sex steroids, so pivotal in the differentiation of the …

Objectives. To identify and study adults (21 years or older) who have a 46, XY karyotype and
presented as infants or children with genital ambiguity, including a small phallus and …