Guidance for the evaluation and treatment of hereditary and acquired thrombophilia

SM Stevens, SC Woller, KA Bauer, R Kasthuri… - Journal of thrombosis …, 2016 - Springer
Thrombophilias are hereditary and/or acquired conditions that predispose patients to
thrombosis. Testing for thrombophilia is commonly performed in patients with venous …

Natural history of venous thromboembolism

C Kearon - Circulation, 2003 - Am Heart Assoc
Most deep vein thromboses (DVTs) start in the calf, and most probably resolve
spontaneously. Thrombi that remain confined to the calf rarely cause leg symptoms or …

Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians evidence-based clinical practice guidelines

C Kearon, SR Kahn, G Agnelli, S Goldhaber… - Chest, 2008 - Elsevier
This chapter about treatment for venous thromboembolic disease is part of the American
College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) …

Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range

J Hirsh, JE Dalen, DR Anderson, L Poller, H Bussey… - Chest, 2001 - journal.chestnet.org
Abbreviations: AFASAK Atrial Fibrillation, Aspirin, Anticoagulation; AMI acute myocardial
infarction; AF atrial fibrillation; CARS Coumadin Aspirin Reinfarction Study; CI confidence …

Genetic susceptibility to venous thrombosis

U Seligsohn, A Lubetsky - New England Journal of Medicine, 2001 - Mass Medical Soc
The annual incidence of venous thrombosis, one of the leading causes of mortality and
morbidity, increases from 1 per 100,000 during childhood to 1 per 100 in old age. 1 In this …

High plasma levels of factor VIII and the risk of recurrent venous thromboembolism

PA Kyrle, E Minar, M Hirschl… - … England Journal of …, 2000 - Mass Medical Soc
Background A high plasma level of factor VIII is a risk factor for venous thromboembolism.
We evaluated the risk of a recurrence of thrombosis after an initial episode of spontaneous …

Thrombophilia, clinical factors, and recurrent venous thrombotic events

SC Christiansen, SC Cannegieter, T Koster… - Jama, 2005 - jamanetwork.com
ContextData on the recurrence rate of venous thrombotic events and the effect of several risk
factors, including thrombophilia, remain controversial. The potential benefit of screening for …

Risk assessment for recurrent venous thrombosis

PA Kyrle, FR Rosendaal, S Eichinger - The Lancet, 2010 - thelancet.com
Venous thrombosis is a common disease that frequently recurs. Recurrence can be
prevented by anticoagulants, albeit at the cost of bleeding. Thus, assessment of the risk of …

Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease

DA Lane, PJ Grant - Blood, The Journal of the American Society …, 2000 - ashpublications.org
The development of thrombotic disorders in humans is one of the most common causes of
morbidity and mortality in the Western world. Thrombotic disease can be classified in broad …

Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation

G Hron, M Kollars, BR Binder, S Eichinger, PA Kyrle - Jama, 2006 - jamanetwork.com
ContextScreening of patients with venous thromboembolism (VTE) for thrombophilic risk
factors is common clinical practice. Because of the large number of risk factors, assessing …