Recent applications of vinyl sulfone motif in drug design and discovery
Vinyl sulfone with electrophilic character is not only a versatile building block for various
organic transformations but also is a key structural unit in a large number of biologically …
organic transformations but also is a key structural unit in a large number of biologically …
Parasite recognition and signaling mechanisms in innate immune responses to malaria
DC Gowda, X Wu - Frontiers in immunology, 2018 - frontiersin.org
Malaria caused by the Plasmodium family of parasites, especially P. falciparum and P. vivax,
is a major health problem in many countries in the tropical and subtropical regions of the …
is a major health problem in many countries in the tropical and subtropical regions of the …
Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …
continues to afflict hundreds of millions of people every year. Infections with malaria …
Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria
SJ Gonzales, RA Reyes, AE Braddom… - Frontiers in …, 2020 - frontiersin.org
Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …
the world's population at risk of Plasmodium infections. The development of an effective …
Host-malaria parasite interactions and impacts on mutual evolution
X Su, C Zhang, DA Joy - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Malaria is the most deadly parasitic disease, affecting hundreds of millions of people
worldwide. Malaria parasites have been associated with their hosts for millions of years …
worldwide. Malaria parasites have been associated with their hosts for millions of years …
Sticking for a cause: the falciparum malaria parasites cytoadherence paradigm
After a successful invasion, malaria parasite Plasmodium falciparum extensively remodels
the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the …
the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the …
Antibodies against Plasmodium falciparum malaria at the molecular level
JP Julien, H Wardemann - Nature Reviews Immunology, 2019 - nature.com
Malaria is a vector-borne disease of global importance, with the vast majority of its life-
threatening cases caused by infection with Plasmodium falciparum parasites. Repeated …
threatening cases caused by infection with Plasmodium falciparum parasites. Repeated …
Fenozyme protects the integrity of the blood–brain barrier against experimental cerebral malaria
Cerebral malaria is a lethal complication of malaria infection characterized by central
nervous system dysfunction and is often not effectively treated by antimalarial combination …
nervous system dysfunction and is often not effectively treated by antimalarial combination …
A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum
X Shang, S Shen, J Tang, X He, Y Zhao… - Nucleic acids …, 2021 - academic.oup.com
Gametocytogenesis, the process by which malaria parasites produce sexual forms that can
infect mosquitoes, is essential for the transmission of malaria. A transcriptional switch of the …
infect mosquitoes, is essential for the transmission of malaria. A transcriptional switch of the …
Pathogenetic mechanisms and treatment targets in cerebral malaria
Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …
humanity for millennia and remains an important public health issue despite advances in its …