Chromosome segregation during cell division requires a bipolar mitotic spindle. Therefore,
how the spindle is formed, maintained, and functions is of fundamental importance for all …

Kinesins, the microtubule-dependent mechanochemical enzymes, power a variety of
intracellular movements. Regulation of Kinesin activity and Kinesin-Cargo interactions …

The Src-family protein tyrosine kinases (SFKs), a subfamily of non-receptor tyrosine kinases,
are ubiquitously expressed in various cell types. Numerous studies have suggested that …

Cell division is a highly regulated and carefully orchestrated process. Understanding the
mechanisms that promote proper cell division is an important step toward unraveling …

Bipolar kinesin-5 motor proteins perform multiple intracellular functions, mainly during
mitotic cell division. Their specialized structural characteristics enable these motors to …

The motor protein Eg5, known as kif11 or kinesin-5, interacts with adjacent microtubules in
the mitotic spindle and plays essential roles in cell division, yet the function of Eg5 in mature …

Numerous posttranslational modifications have been described in kinesins, but their
consequences on motor mechanics are largely unknown. We investigated one of these …

UFMylation is a highly conserved ubiquitin-like post-translational modification that catalyzes
the covalent linkage of UFM1 to its target proteins. This modification plays a critical role in …

Although centrosomes help organize spindles in most cell types, oocytes of most species
lack these structures. During acentrosomal spindle assembly in C. elegans oocytes …

Friday, February 26, 2021 289a chromosomes toward microtubule plus ends, indicating that
mutant motors are active and R149Q and V475G are not simply loss of function mutations …