Recent progress and challenges in the treatment of spinal cord injury

T Tian, S Zhang, M Yang - Protein & cell, 2023 - academic.oup.com
Spinal cord injury (SCI) disrupts the structural and functional connectivity between the higher
center and the spinal cord, resulting in severe motor, sensory, and autonomic dysfunction …

Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances

SM Hosseini, B Borys, S Karimi-Abdolrezaee - Brain, 2024 - academic.oup.com
Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …

[HTML][HTML] BDNF guides neural stem cell-derived axons to ventral interneurons and motor neurons after spinal cord injury

Y Li, A Tran, L Graham, J Brock, MH Tuszynski… - Experimental neurology, 2023 - Elsevier
Neural stem cells (NSCs) implanted into sites of spinal cord injury (SCI) extend very large
numbers of new axons over very long distances caudal to the lesion site, and support partial …

AAV2-mediated and hypoxia response element-directed expression of bFGF in neural stem cells showed therapeutic effects on spinal cord injury in rats

S Zhu, Y Ying, J Ye, M Chen, Q Wu, H Dou, W Ni… - Cell death & …, 2021 - nature.com
Neural stem cell (NSCs) transplantation has been one of the hot topics in the repair of spinal
cord injury (SCI). Fibroblast growth factor (FGF) is considered a promising nerve injury …

Sustained delivery of neurotrophic factors to treat spinal cord injury

A Muheremu, L Shu, J Liang, A Aili… - Translational …, 2021 - degruyter.com
Acute spinal cord injury (SCI) is a devastating condition that results in tremendous physical
and psychological harm and a series of socioeconomic problems. Although neurons in the …

Therapeutic strategies targeting respiratory recovery after spinal cord injury: from preclinical development to clinical translation

P Michel-Flutot, MA Lane, AC Lepore, S Vinit - Cells, 2023 - mdpi.com
High spinal cord injuries (SCIs) lead to permanent functional deficits, including respiratory
dysfunction. Patients living with such conditions often rely on ventilatory assistance to …

The thrombin receptor modulates astroglia‐neuron trophic coupling and neural repair after spinal cord injury

HN Kim, EM Triplet, M Radulovic, S Bouchal… - Glia, 2021 - Wiley Online Library
Excessive activation of the thrombin receptor, protease activated receptor 1 (PAR1) is
implicated in diverse neuropathologies from neurodegenerative conditions to neurotrauma …

脊髓损伤再生修复中的问题与挑战

田婷, 李晓光 - 中国组织工程研究, 2021 - cjter.com
摘要背景: 脊髓损伤导致严重的感觉, 运动功能障碍, 反射异常以及自主神经功能紊乱.
目前脊髓损伤尚无有效的临床治疗措施. 近年来, 研究人员开发出多种新型治疗方案 …

Phrenic motor neuron survival below cervical spinal cord hemisection

LL Allen, NL Nichols, ZA Asa, AT Emery… - Experimental …, 2021 - Elsevier
Cervical spinal cord injury (cSCI) severs bulbospinal projections to respiratory motor
neurons, paralyzing respiratory muscles below the injury. C2 spinal hemisection (C2Hx) is a …

[HTML][HTML] LAR inhibitory peptide promotes recovery of diaphragm function and multiple forms of respiratory neural circuit plasticity after cervical spinal cord injury

L Cheng, A Sami, B Ghosh, MW Urban… - Neurobiology of …, 2021 - Elsevier
Chondroitin sulfate proteoglycans (CSPGs), up-regulated in and around the lesion after
traumatic spinal cord injury (SCI), are key extracellular matrix inhibitory molecules that limit …